75865 20200117212657.0 doi 10.1016/j.bpj.2018.10.009 sideral 108823 ART-2018-108823 eng Raffa, V. Piconewton Mechanical Forces Promote Neurite Growth 2018 Access copy available to the general public Unrestricted Investigations over half a century have indicated that mechanical forces induce neurite growth, with neurites elongating at a rate of 0.1–0.3 µm h-1 pN-1 when mechanical force exceeds a threshold, with this being identified as 400–1000 pN for neurites of PC12 cells. In this article, we demonstrate that neurite elongation of PC12 cells proceeds at the same previously identified rate on application of mechanical tension of ~1 pN, which is significantly lower than the force generated in vivo by axons and growth cones. This observation raises the possibility that mechanical tension may act as an endogenous signal used by neurons for promoting neurite elongation. info:eu-repo/grantAgreement/EC/FP7/622122/EU/Magnetically Enhanced Controlled Axonal Regeneration/MECAR info:eu-repo/semantics/openAccess by-nc-nd http://creativecommons.org/licenses/by-nc-nd/3.0/es/ 3.665 2018 BIOPHYSICS 20 / 72 = 0.278 2018 Q2 T1 2.018 2018 Biophysics 2018 Q1 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion Falcone, F. De Vincentiis, S. Falconieri, A. (orcid)0000-0001-9359-0019 Calatayud, M.P. (orcid)0000-0003-1558-9279 Goya, G.F. Universidad de Zaragoza Cuschieri, A. 2003 395 Universidad de Zaragoza Dpto. Física Materia Condensa. Área Física Materia Condensada 115 (2018), [8 pp] Biophys. j. BIOPHYSICAL JOURNAL 0006-3495 237311 http://zaguan.unizar.es/record/75865/files/texto_completo.pdf Versión publicada 117958 http://zaguan.unizar.es/record/75865/files/texto_completo.jpg?subformat=icon icon Versión publicada oai:zaguan.unizar.es:75865 articulos driver 2020-01-17-21:23:43 ARTICLE