000075920 001__ 75920
000075920 005__ 20240912131720.0
000075920 0247_ $$2doi$$a10.1016/j.jelectrocard.2015.06.006
000075920 0248_ $$2sideral$$a92041
000075920 037__ $$aART-2015-92041
000075920 041__ $$aeng
000075920 100__ $$0(orcid)0000-0003-3183-4107$$aMincholé, A.
000075920 245__ $$aECG-based estimation of dispersion of APD restitution as a tool to stratify sotalol-induced arrhythmic risk
000075920 260__ $$c2015
000075920 5060_ $$aAccess copy available to the general public$$fUnrestricted
000075920 5203_ $$aBackground
Increased spatial dispersion of restitution properties has been associated to arrhythmic risk. An ECG-based index quantifying restitution dispersion, DRest, is evaluated in patients who experienced Torsades de Pointes (TdP) under sotalol challenge and compared with the response in healthy subjects.
Methods and Results
ECG recordings were analyzed for quantification of DRest and QTc, among others biomarkers. DRest provides improved discrimination following sotalol administration between TdP and healthy subjects ([min–max]: [0.18–0.22] vs [0.02–0.12]), compared to other biomarkers including QTc ([436–548 ms] vs [376–467 ms]). Results in healthy subjects are in agreement with simulations of sotalol effects on a human tissue electrophysiological model.
Conclusions
This case study supports the potential of DRest for improved arrhythmia risk stratification even with QTc values below 450 ms.
000075920 536__ $$9info:eu-repo/grantAgreement/ES/MINECO/TEC2013-42140-R$$9info:eu-repo/grantAgreement/ES/MINECO/TIN2013-41998-R
000075920 540__ $$9info:eu-repo/semantics/openAccess$$aby$$uhttp://creativecommons.org/licenses/by/3.0/es/
000075920 590__ $$a1.29$$b2015
000075920 591__ $$aCARDIAC & CARDIOVASCULAR SYSTEMS$$b93 / 124 = 0.75$$c2015$$dQ3$$eT3
000075920 592__ $$a0.559$$b2015
000075920 593__ $$aCardiology and Cardiovascular Medicine$$c2015$$dQ2
000075920 655_4 $$ainfo:eu-repo/semantics/article$$vinfo:eu-repo/semantics/publishedVersion
000075920 700__ $$aBueno-Orovio, A.
000075920 700__ $$0(orcid)0000-0003-3434-9254$$aLaguna, P.$$uUniversidad de Zaragoza
000075920 700__ $$0(orcid)0000-0002-1960-407X$$aPueyo, E.$$uUniversidad de Zaragoza
000075920 700__ $$aRodriguez, B.
000075920 7102_ $$15008$$2800$$aUniversidad de Zaragoza$$bDpto. Ingeniería Electrón.Com.$$cÁrea Teoría Señal y Comunicac.
000075920 773__ $$g48, 5 (2015), 867-873$$pJ. electrocardiol.$$tJOURNAL OF ELECTROCARDIOLOGY$$x0022-0736
000075920 8564_ $$s445358$$uhttps://zaguan.unizar.es/record/75920/files/texto_completo.pdf$$yVersión publicada
000075920 8564_ $$s109729$$uhttps://zaguan.unizar.es/record/75920/files/texto_completo.jpg?subformat=icon$$xicon$$yVersión publicada
000075920 909CO $$ooai:zaguan.unizar.es:75920$$particulos$$pdriver
000075920 951__ $$a2024-09-12-13:15:34
000075920 980__ $$aARTICLE