75920 20240912131720.0 doi 10.1016/j.jelectrocard.2015.06.006 sideral 92041 ART-2015-92041 eng Mincholé, A. (orcid)0000-0003-3183-4107 ECG-based estimation of dispersion of APD restitution as a tool to stratify sotalol-induced arrhythmic risk 2015 Access copy available to the general public Unrestricted Background Increased spatial dispersion of restitution properties has been associated to arrhythmic risk. An ECG-based index quantifying restitution dispersion, DRest, is evaluated in patients who experienced Torsades de Pointes (TdP) under sotalol challenge and compared with the response in healthy subjects. Methods and Results ECG recordings were analyzed for quantification of DRest and QTc, among others biomarkers. DRest provides improved discrimination following sotalol administration between TdP and healthy subjects ([min–max]: [0.18–0.22] vs [0.02–0.12]), compared to other biomarkers including QTc ([436–548 ms] vs [376–467 ms]). Results in healthy subjects are in agreement with simulations of sotalol effects on a human tissue electrophysiological model. Conclusions This case study supports the potential of DRest for improved arrhythmia risk stratification even with QTc values below 450 ms. info:eu-repo/grantAgreement/ES/MINECO/TEC2013-42140-R info:eu-repo/grantAgreement/ES/MINECO/TIN2013-41998-R info:eu-repo/semantics/openAccess by http://creativecommons.org/licenses/by/3.0/es/ 1.29 2015 CARDIAC & CARDIOVASCULAR SYSTEMS 93 / 124 = 0.75 2015 Q3 T3 0.559 2015 Cardiology and Cardiovascular Medicine 2015 Q2 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion Bueno-Orovio, A. Laguna, P. Universidad de Zaragoza (orcid)0000-0003-3434-9254 Pueyo, E. Universidad de Zaragoza (orcid)0000-0002-1960-407X Rodriguez, B. 5008 800 Universidad de Zaragoza Dpto. Ingeniería Electrón.Com. Área Teoría Señal y Comunicac. 48, 5 (2015), 867-873 J. electrocardiol. JOURNAL OF ELECTROCARDIOLOGY 0022-0736 445358 http://zaguan.unizar.es/record/75920/files/texto_completo.pdf Versión publicada 109729 http://zaguan.unizar.es/record/75920/files/texto_completo.jpg?subformat=icon icon Versión publicada oai:zaguan.unizar.es:75920 articulos driver 2024-09-12-13:15:34 ARTICLE