75922 20200117213749.0 doi 10.1016/j.cej.2017.12.024 sideral 105297 ART-2018-105297 eng (orcid)0000-0002-4678-7465 Uson, L. Single phase microreactor for the continuous, high-temperature synthesis of <4¿nm superparamagnetic iron oxide nanoparticles 2018 Access copy available to the general public Unrestricted The reproducibility of key nanomaterial features is essential in nanomedicine applications where small changes of physical characteristics often lead to a very different behavior. In this regard, continuous microreactors are often advocated as a means to achieve highly precise synthesis of nanomaterials. However, when the synthesis must take place at high temperatures the use of these devices becomes restricted in terms of materials and practical problems (e.g. plugging of microchannels). Here we present the continuous synthesis of ultrasmall superparamagnetic iron oxide nanoparticles (SPIONs) through a polyol-based process at high temperatures (>200 °C). The microfluidic reactor designed allows SPION production at residence times under 1 min, was able to work continuously for 8 h without channel blockage and reached high production yields by coupling microreactors using stacked plates. The effect of operating conditions was optimized to produce homogeneous particles with a narrow particle size distribution. In summary, the microreactor developed in this work enables easy-to scale up, reproducible continuous production of SPIONs. info:eu-repo/grantAgreement/EC/FP7/614715/EU/A Photo-triggered On-demand Drug Delivery System for Chronic Pain/NANOHEDONISM info:eu-repo/grantAgreement/EC/FP7/321642/EU/Development of a microfluidic platform to produce nanomaterials and assessment on new nanotechnology applications/PLATFORM2NANO info:eu-repo/grantAgreement/ES/DGA/FSE info:eu-repo/semantics/openAccess by-nc-nd http://creativecommons.org/licenses/by-nc-nd/3.0/es/ 8.355 2018 ENGINEERING, ENVIRONMENTAL 2 / 52 = 0.038 2018 Q1 T1 ENGINEERING, CHEMICAL 6 / 138 = 0.043 2018 Q1 T1 2.066 2018 Chemical Engineering (miscellaneous) 2018 Q1 Chemistry (miscellaneous) 2018 Q1 Industrial and Manufacturing Engineering 2018 Q1 Environmental Chemistry 2018 Q1 Engineering (miscellaneous) 2018 Q4 info:eu-repo/semantics/article info:eu-repo/semantics/acceptedVersion (orcid)0000-0003-3165-0156 Arruebo, M. Universidad de Zaragoza (orcid)0000-0002-6873-5244 Sebastian, V. Universidad de Zaragoza (orcid)0000-0002-8701-9745 Santamaria, J. Universidad de Zaragoza 5005 555 Universidad de Zaragoza Dpto. Ing.Quím.Tecnol.Med.Amb. Área Ingeniería Química 340 (2018), 66-72 Chem. eng. j. Chemical Engineering Journal 1385-8947 550670 http://zaguan.unizar.es/record/75922/files/texto_completo.pdf Postprint 45556 http://zaguan.unizar.es/record/75922/files/texto_completo.jpg?subformat=icon icon Postprint oai:zaguan.unizar.es:75922 articulos driver 2020-01-17-21:31:38 ARTICLE