000075952 001__ 75952
000075952 005__ 20201023165833.0
000075952 0247_ $$2doi$$a10.1002/ijc.31858
000075952 0248_ $$2sideral$$a109033
000075952 037__ $$aART-2018-109033
000075952 041__ $$aeng
000075952 100__ $$0(orcid)0000-0002-3545-2707$$aGargallo, C.J.$$uUniversidad de Zaragoza
000075952 245__ $$aGenetic susceptibility in the development of colorectal adenomas according to family history of colorectal cancer
000075952 260__ $$c2018
000075952 5060_ $$aAccess copy available to the general public$$fUnrestricted
000075952 5203_ $$aOur study aimed to evaluate the relevance of genetic susceptibility in the development of colorectal adenomas (CRA) and its relationship with the presence of family history of colorectal cancer (CRC). Genomic DNA from 750 cases (first degree relatives of patients with CRC) and 750 controls (subjects with no family history of CRC) was genotyped for 99 single nucleotide polymorphisms (SNPs) previously associated with CRC/CRA risk by GWAS and candidate gene studies by using the MassArray™ (Sequenom) platform. Cases and controls were matched by gender, age and histological lesion. Eight hundred and fifty-eight patients showed no neoplastic lesions, whereas 288 patients showed low-risk adenomas, and 354 patients presented high-risk adenomas. Two SNPs (rs10505477, rs6983267) in the CASC8 gene were associated with a reduced risk of CRA in controls (log-additive models, OR: 0.67, 95%CI:0.54–0.83, and OR:0.66, 95%CI:0.54–0.84, respectively). Stratified analysis by histological lesion revealed the association of rs10505477 and rs6983267 variants with reduced risk of low- and high-risk adenomas in controls, being this effect stronger in low-risk adenomas (log-additive models, OR:0.63, 95%CI:0.47–0.84 and OR:0.64, 95%CI:0.47–0.86, respectively). Moreover, 2 SNPs (rs10795668, rs11255841) in the noncoding LINC00709 gene were significantly associated with a reduced risk of low-risk adenomas in cases (recessive models, OR:0.22, 95%CI:0.06–0.72, and OR:0.08, 95%CI:0.03–0.61) and controls (dominant models, OR:0.50, 95%CI:0.34–0.75, and OR:0.52, 95%CI:0.35–0.78, respectively). In conclusion, some variants associated with CRC risk (rs10505477, rs6983267, rs10795668 and rs11255841) are also involved in the susceptibility to CRA and specific subtypes. These associations are influenced by the presence of family history of CRC.
000075952 540__ $$9info:eu-repo/semantics/openAccess$$aby-nc$$uhttp://creativecommons.org/licenses/by-nc/3.0/es/
000075952 590__ $$a4.982$$b2018
000075952 591__ $$aONCOLOGY$$b51 / 229 = 0.223$$c2018$$dQ1$$eT1
000075952 592__ $$a3.276$$b2018
000075952 593__ $$aOncology$$c2018$$dQ1
000075952 593__ $$aCancer Research$$c2018$$dQ1
000075952 655_4 $$ainfo:eu-repo/semantics/article$$vinfo:eu-repo/semantics/publishedVersion
000075952 700__ $$0(orcid)0000-0001-5932-2889$$aLanas, Á.$$uUniversidad de Zaragoza
000075952 700__ $$aCarrera-Lasfuentes, P.
000075952 700__ $$0(orcid)0000-0003-2280-9372$$aFerrandez, Á.
000075952 700__ $$aQuintero, E.
000075952 700__ $$aCarrillo, M.
000075952 700__ $$aAlonso-Abreu, I.
000075952 700__ $$aGarcía-Gonzalez, M.A.
000075952 7102_ $$11007$$2610$$aUniversidad de Zaragoza$$bDpto. Medicina, Psiqu. y Derm.$$cArea Medicina
000075952 773__ $$g144 (2018), 489-502$$pInt. j. cancer$$tINTERNATIONAL JOURNAL OF CANCER$$x0020-7136
000075952 8564_ $$s280752$$uhttps://zaguan.unizar.es/record/75952/files/texto_completo.pdf$$yVersión publicada
000075952 8564_ $$s104824$$uhttps://zaguan.unizar.es/record/75952/files/texto_completo.jpg?subformat=icon$$xicon$$yVersión publicada
000075952 909CO $$ooai:zaguan.unizar.es:75952$$particulos$$pdriver
000075952 951__ $$a2020-10-23-16:54:59
000075952 980__ $$aARTICLE