000075977 001__ 75977
000075977 005__ 20191127155459.0
000075977 0247_ $$2doi$$a10.3389/fimmu.2018.02549
000075977 0248_ $$2sideral$$a109010
000075977 037__ $$aART-2018-109010
000075977 041__ $$aeng
000075977 100__ $$0(orcid)0000-0002-9730-2210$$aArias, M.$$uUniversidad de Zaragoza
000075977 245__ $$aPreparations for invasion: Modulation of host lung immunity during pulmonary aspergillosis by gliotoxin and other fungal secondary metabolites
000075977 260__ $$c2018
000075977 5060_ $$aAccess copy available to the general public$$fUnrestricted
000075977 5203_ $$aPulmonary aspergillosis is a severe infectious disease caused by some members of the Aspergillus genus, that affects immunocompetent as well as immunocompromised patients. Among the different disease forms, Invasive Aspergillosis is the one causing the highest mortality, mainly, although not exclusively, affecting neutropenic patients. This genus is very well known by humans, since different sectors like pharmaceutical or food industry have taken advantage of the biological activity of some molecules synthetized by the fungus, known as secondary metabolites, including statins, antibiotics, fermentative compounds or colorants among others. However, during infection, in response to a hostile host environment, the fungal secondary metabolism is activated, producing different virulence factors to increase its survival chances. Some of these factors also contribute to fungal dissemination and invasion of adjacent and distant organs. Among the different secondary metabolites produced by Aspergillus spp. Gliotoxin (GT) is the best known and better characterized virulence factor. It is able to generate reactive oxygen species (ROS) due to the disulfide bridge present in its structure. It also presents immunosuppressive activity related with its ability to kill mammalian cells and/or inactivate critical immune signaling pathways like NFkB. In this comprehensive review, we will briefly give an overview of the lung immune response against Aspergillus as a preface to analyse the effect of different secondary metabolites on the host immune response, with a special attention to GT. We will discuss the results reported in the literature on the context of the animal models employed to analyse the role of GT as virulence factor, which is expected to greatly depend on the immune status of the host: why should you hide when nobody is seeking for you? Finally, GT immunosuppressive activity will be related with different human diseases predisposing to invasive aspergillosis in order to have a global view on the potential of GT to be used as a target to treat IA.
000075977 536__ $$9info:eu-repo/grantAgreement/ES/DGA/FSE$$9info:eu-repo/grantAgreement/ES/MINECO/FJCI-2017-31629$$9info:eu-repo/grantAgreement/ES/MINECO/SAF2014-54763-C2-1-R$$9info:eu-repo/grantAgreement/ES/MINECO/SAF2014-54763-C2-2-R$$9info:eu-repo/grantAgreement/ES/MINECO/SAF2017-83120-C2-1-R
000075977 540__ $$9info:eu-repo/semantics/openAccess$$aby$$uhttp://creativecommons.org/licenses/by/3.0/es/
000075977 590__ $$a4.716$$b2018
000075977 591__ $$aIMMUNOLOGY$$b42 / 157 = 0.268$$c2018$$dQ2$$eT1
000075977 592__ $$a2.021$$b2018
000075977 593__ $$aImmunology and Allergy$$c2018$$dQ1
000075977 593__ $$aImmunology$$c2018$$dQ1
000075977 655_4 $$ainfo:eu-repo/semantics/review$$vinfo:eu-repo/semantics/publishedVersion
000075977 700__ $$0(orcid)0000-0002-1861-5981$$aSantiago, L.$$uUniversidad de Zaragoza
000075977 700__ $$aVidal-García, M.
000075977 700__ $$aRedrado, S.
000075977 700__ $$0(orcid)0000-0001-7328-2094$$aLanuza, P.$$uUniversidad de Zaragoza
000075977 700__ $$aComas, L.
000075977 700__ $$aDomingo, M.P.
000075977 700__ $$0(orcid)0000-0001-7294-245X$$aRezusta, A.$$uUniversidad de Zaragoza
000075977 700__ $$aGálvez, E.M.
000075977 7102_ $$11008$$2630$$aUniversidad de Zaragoza$$bDpto. Microb.Med.Pr.,Sal.Públ.$$cÁrea Microbiología
000075977 7102_ $$11008$$2566$$aUniversidad de Zaragoza$$bDpto. Microb.Med.Pr.,Sal.Públ.$$cÁrea Inmunología
000075977 7102_ $$11002$$2060$$aUniversidad de Zaragoza$$bDpto. Bioq.Biolog.Mol. Celular$$cÁrea Bioquímica y Biolog.Mole.
000075977 773__ $$g9, NOV (2018), 2549 [12 pp]$$pFront. immunol.$$tFrontiers in Immunology$$x1664-3224
000075977 8564_ $$s220458$$uhttps://zaguan.unizar.es/record/75977/files/texto_completo.pdf$$yVersión publicada
000075977 8564_ $$s11266$$uhttps://zaguan.unizar.es/record/75977/files/texto_completo.jpg?subformat=icon$$xicon$$yVersión publicada
000075977 909CO $$ooai:zaguan.unizar.es:75977$$particulos$$pdriver
000075977 951__ $$a2019-11-27-15:49:38
000075977 980__ $$aARTICLE