000075983 001__ 75983
000075983 005__ 20200729203742.0
000075983 0247_ $$2doi$$a10.1186/s12931-018-0923-8
000075983 0248_ $$2sideral$$a108893
000075983 037__ $$aART-2018-108893
000075983 041__ $$aeng
000075983 100__ $$aSoler-Palacin, P.
000075983 245__ $$aPrimary immunodeficiency diseases in lung disease: warning signs, diagnosis and management
000075983 260__ $$c2018
000075983 5060_ $$aAccess copy available to the general public$$fUnrestricted
000075983 5203_ $$aBACKGROUND:
Pulmonary complications are common in primary immunodeficiency diseases (PID) and contribute to morbidity and mortality in these patients. However, their varied presentation and a general lack of awareness of PID in this setting make early diagnosis and treatment difficult. The aim of this study was to define the warning signs of PID in patients with respiratory manifestations, the necessary diagnostic tests, and the therapeutic management of both children and adults.
METHODS:
A review of the literature was performed, and 43 PID interdisciplinary specialists were consulted.
RESULTS:
This document identifies the pulmonary and extrapulmonary manifestations that should prompt a suspicion of PID, the immunological and respiratory tests that should be included in the diagnostic process according to the level of care, recommendations regarding the use of immunoglobulin replacement therapy according to the specific immunodeficiency, and the minimum recommended immunological and pulmonary monitoring in these patients.
CONCLUSIONS:
This document is the first to combine scientific evidence with the opinion of a broad panel of experts specializing in the treatment of patients with immunodeficiencies. It aims to provide a useful tool for all practitioners who are regularly involved in the management of these patients.
000075983 540__ $$9info:eu-repo/semantics/openAccess$$aby$$uhttp://creativecommons.org/licenses/by/3.0/es/
000075983 590__ $$a3.829$$b2018
000075983 591__ $$aRESPIRATORY SYSTEM$$b20 / 63 = 0.317$$c2018$$dQ2$$eT1
000075983 592__ $$a1.409$$b2018
000075983 593__ $$aPulmonary and Respiratory Medicine$$c2018$$dQ1
000075983 655_4 $$ainfo:eu-repo/semantics/article$$vinfo:eu-repo/semantics/publishedVersion
000075983 700__ $$ade Gracia, J.
000075983 700__ $$aGonzalez-Granado, L.I.
000075983 700__ $$0(orcid)0000-0003-2993-5478$$aMartin, C.$$uUniversidad de Zaragoza
000075983 700__ $$aRodriguez-Gallego, C.
000075983 700__ $$aSanchez-Ramon, S.
000075983 7102_ $$11008$$2630$$aUniversidad de Zaragoza$$bDpto. Microb.Med.Pr.,Sal.Públ.$$cÁrea Microbiología
000075983 773__ $$g19 (2018), 219 [13 pp]$$pRespir. res.$$tRespiratory research$$x1465-9921
000075983 8564_ $$s371032$$uhttps://zaguan.unizar.es/record/75983/files/texto_completo.pdf$$yVersión publicada
000075983 8564_ $$s101272$$uhttps://zaguan.unizar.es/record/75983/files/texto_completo.jpg?subformat=icon$$xicon$$yVersión publicada
000075983 909CO $$ooai:zaguan.unizar.es:75983$$particulos$$pdriver
000075983 951__ $$a2020-07-29-20:20:26
000075983 980__ $$aARTICLE