doi:10.3233/JAD-170014engMolina-Sotomayor, E.Arreguin-Moreno, R.Rodriguez, F.Pradas, F.Leon, J.A.Gonzalez-Jurado, J.A.Effects of exercise on the cognition of older women treated with lovastatinART-2018-108908Introduction: The deterioration of cognition is highly predominant in older adults. Objective: The aim of this study was to analyse the effects of a walk program on the cognition and blood concentration of lipids in women over 60 years of age who were being treated with Lovastatin. Materials and methods: Participants were distributed in two groups: an exercise group (EG, n=45) with aerobic training and an inactive sedentary group (SG, n=22). The cognitive state of the subjects was assessed through the Spanish Mini-Cog Test version of the MMSE; lipoproteins were quantified using a lipid profile test and the cardiorespiratory fitness was measured using the 6 min Walk Test (6MWT). Results: EG showed a significant increase (p<0.05) in cardiorespiratory fitness and in HDL-C concentrations. Furthermore, the results from the cognition tests showed a large effect size in spatial orientation and attention and calculation. The decrease in LDL-C was not significant (p>0.05). Conclusion: A controlled and progressive walk program for older women treated with Lovastatin may induce a boost of brain activity linked to HDL-C, which could delay cognitive impairment.2018http://zaguan.unizar.es/record/7600210.3233/JAD-170014http://zaguan.unizar.es/record/76002oai:zaguan.unizar.es:76002Biomedica 38, 4 (2018), [33 pp]by-nchttp://creativecommons.org/licenses/by-nc/3.0/es/info:eu-repo/semantics/openAccess