76036 20201009175922.0 doi 10.1016/j.ijpharm.2017.04.022 sideral 98969 ART-2017-98969 eng Aragon, J. Universidad de Zaragoza Laser-treated electrospun fibers loaded with nano-hydroxyapatite for bone tissue engineering 2017 Access copy available to the general public Unrestricted Core-shell polycaprolactone/polycaprolactone (PCL/PCL) and polycaprolactone/polyvinyl acetate (PCL/PVAc) electrospun fibers loaded with synthesized nanohydroxyapatite (HAn) were lased treated to create microporosity. The prepared materials were characterized by XRD, FTIR, TEM and SEM. Uniform and randomly oriented beadless fibrous structures were obtained in all cases. Fibers diameters were in the 150–300 nm range. Needle-like HAn nanoparticles with mean diameters of 20 nm and length of approximately 150 nm were mostly encase inside the fibers. Laser treated materials present micropores with diameters in the range 70–120 µm for PCL-HAn/PCL fibers and in the 50–90 µm range for PCL-HAn/PVAC material. Only samples containing HAn presented bioactivity after incubation during 30 days in simulated body fluid. All scaffolds presented high viability, very low mortality, and human osteoblast proliferation. Biocompatibility was increased by laser treatment due to the surface and porosity modification. info:eu-repo/grantAgreement/ES/MINECO/CTQ2014-52384-R info:eu-repo/semantics/openAccess by-nc-nd http://creativecommons.org/licenses/by-nc-nd/3.0/es/ 3.862 2017 PHARMACOLOGY & PHARMACY 46 / 261 = 0.176 2017 Q1 T1 1.172 2017 Pharmaceutical Science 2017 Q1 info:eu-repo/semantics/article info:eu-repo/semantics/acceptedVersion (orcid)0000-0003-3363-2912 Navascues, N. (orcid)0000-0003-2293-363X Mendoza, G. (orcid)0000-0002-2966-9088 Irusta, S. Universidad de Zaragoza 5005 555 Universidad de Zaragoza Dpto. Ing.Quím.Tecnol.Med.Amb. Área Ingeniería Química 525, 1 (2017), 112-122 Int. j. pharm. International Journal of Pharmaceutics 0378-5173 1178370 http://zaguan.unizar.es/record/76036/files/texto_completo.pdf Postprint 44300 http://zaguan.unizar.es/record/76036/files/texto_completo.jpg?subformat=icon icon Postprint oai:zaguan.unizar.es:76036 articulos driver 2020-10-09-17:46:36 ARTICLE