000076052 001__ 76052
000076052 005__ 20191126134635.0
000076052 0247_ $$2doi$$a10.1016/j.envpol.2018.01.008
000076052 0248_ $$2sideral$$a104556
000076052 037__ $$aART-2018-104556
000076052 041__ $$aeng
000076052 100__ $$aGrau-Perez, M.
000076052 245__ $$aArsenic exposure, diabetes-related genes and diabetes prevalence in a general population from Spain
000076052 260__ $$c2018
000076052 5060_ $$aAccess copy available to the general public$$fUnrestricted
000076052 5203_ $$aInorganic arsenic exposure may be associated with diabetes, but the evidence at low-moderate levels is not sufficient. Polymorphisms in diabetes-related genes have been involved in diabetes risk. We evaluated the association of inorganic arsenic exposure on diabetes in the Hortega Study, a representative sample of a general population from Valladolid, Spain. Total urine arsenic was measured in 1451 adults. Urine arsenic speciation was available in 295 randomly selected participants. To account for the confounding introduced by non-toxic seafood arsenicals, we designed a multiple imputation model to predict the missing arsenobetaine levels. The prevalence of diabetes was 8.3%. The geometric mean of total arsenic was 66.0 µg/g. The adjusted odds ratios (95% confidence interval) for diabetes comparing the highest with the lowest tertile of total arsenic were 1.76 (1.01, 3.09) and 2.14 (1.47, 3.11) before and after arsenobetaine adjustment, respectively. Polymorphisms in several genes including IL8RA, TXN, NR3C2, COX5A and GCLC showed suggestive differential associations of urine total arsenic with diabetes. The findings support the role of arsenic on diabetes and the importance of controlling for seafood arsenicals in populations with high seafood intake. Suggestive arsenic-gene interactions require confirmation in larger studies.
000076052 536__ $$9info:eu-repo/grantAgreement/ES/ISCIII/CB06-03$$9info:eu-repo/grantAgreement/ES/ISCIII/FIS/CP12-03080$$9info:eu-repo/grantAgreement/ES/ISCIII/PI10-0082$$9info:eu-repo/grantAgreement/ES/ISCIII/PI11-00726$$9info:eu-repo/grantAgreement/ES/ISCIII/PI13-01848$$9info:eu-repo/grantAgreement/ES/ISCIII/PI15-00071$$9info:eu-repo/grantAgreement/ES/Spanish Ministry of Health/CIBERDEM CB07-08-018$$9info:eu-repo/grantAgreement/ES/Spanish Ministry of Health/CIBERobn CB12-03-30016$$9info:eu-repo/grantAgreement/ES/Spanish Ministry of Health/CIBER02-08-2009
000076052 540__ $$9info:eu-repo/semantics/openAccess$$aAll rights reserved$$uhttp://www.europeana.eu/rights/rr-f/
000076052 590__ $$a5.714$$b2018
000076052 591__ $$aENVIRONMENTAL SCIENCES$$b25 / 250 = 0.1$$c2018$$dQ1$$eT1
000076052 592__ $$a1.673$$b2018
000076052 593__ $$aHealth, Toxicology and Mutagenesis$$c2018$$dQ1
000076052 593__ $$aToxicology$$c2018$$dQ1
000076052 593__ $$aPollution$$c2018$$dQ1
000076052 593__ $$aMedicine (miscellaneous)$$c2018$$dQ1
000076052 655_4 $$ainfo:eu-repo/semantics/article$$vinfo:eu-repo/semantics/acceptedVersion
000076052 700__ $$aNavas-Acien, A.
000076052 700__ $$aGalan-Chilet, I.
000076052 700__ $$aBriongos-Figuero, L.S.
000076052 700__ $$aMorchon-Simon, D.
000076052 700__ $$aBermudez, J.D.
000076052 700__ $$aCrainiceanu, C.M.
000076052 700__ $$ade Marco, G.
000076052 700__ $$aRentero-Garrido, P.
000076052 700__ $$aGarcia-Barrera, T.
000076052 700__ $$aGomez-Ariza, J.L.
000076052 700__ $$0(orcid)0000-0002-9887-2629$$aCasasnovas, J.A.$$uUniversidad de Zaragoza
000076052 700__ $$aMartin-Escudero, J.C.
000076052 700__ $$aRedon, J.
000076052 700__ $$aChaves, F.J.
000076052 700__ $$aTellez-Plaza, M.
000076052 7102_ $$11007$$2610$$aUniversidad de Zaragoza$$bDpto. Medicina, Psiqu. y Derm.$$cArea Medicina
000076052 773__ $$g235 (2018), 948-955$$pEnviron. pollut.$$tEnvironmental Pollution$$x0269-7491
000076052 8564_ $$s790818$$uhttps://zaguan.unizar.es/record/76052/files/texto_completo.pdf$$yPostprint
000076052 8564_ $$s12621$$uhttps://zaguan.unizar.es/record/76052/files/texto_completo.jpg?subformat=icon$$xicon$$yPostprint
000076052 909CO $$ooai:zaguan.unizar.es:76052$$particulos$$pdriver
000076052 951__ $$a2019-11-26-13:43:24
000076052 980__ $$aARTICLE