000076053 001__ 76053
000076053 005__ 20200103141019.0
000076053 0247_ $$2doi$$a10.1039/c7nr07345c
000076053 0248_ $$2sideral$$a104577
000076053 037__ $$aART-2018-104577
000076053 041__ $$aeng
000076053 100__ $$0(orcid)0000-0003-2293-363X$$aMendoza, Gracia
000076053 245__ $$aNear infrared dye-labelled polymeric micro- and nanomaterials:: In vivo imaging and evaluation of their local persistence
000076053 260__ $$c2018
000076053 5060_ $$aAccess copy available to the general public$$fUnrestricted
000076053 5203_ $$aThe use of micro- and nanomaterials as carriers of therapeutic molecules can enhance the efficiency of treatments while avoiding side effects thanks to the development of controlled drug delivery systems. The binding of a dye to a drug or to a drug carrier has opened up a wide range of possibilities for an effective in vivo optical tracing of drug biodistribution by using non-invasive real-time technologies prior to their potential use as therapeutic vectors. Here, we describe the fluorescent tagging of polymeric micro- and nanomaterials based on poly(lactic-co-glycolic) acid and on the thermoresponsive poly(N-isopropylacrylamide) with the fluorescent probe IR-820 which was chemically modified for its covalent coupling to the materials. The chemical modification of the dye and the polymers yielded micro- and nanoparticulated labelled materials to be potentially used as drug depots of different therapeutic molecules. In vitro biological studies revealed their reduced cytotoxicity. A spatiotemporal in vivo micro- and nanoparticle tracking allowed the evaluation of the biodistribution of materials showing their local persistence and high biocompatibility after pathological studies. These results underline the suitability of these materials for the local, sustained, not harmful and/or on-demand drug delivery and the remarkable importance of evaluating the biodistribution of materials and tissue persistence for their use as local drug depots.
000076053 536__ $$9info:eu-repo/grantAgreement/ES/ISCIII/CIBER-BBN$$9info:eu-repo/grantAgreement/EC/FP7/614715/EU/A Photo-triggered On-demand Drug Delivery System for Chronic Pain/NANOHEDONISM
000076053 540__ $$9info:eu-repo/semantics/openAccess$$aAll rights reserved$$uhttp://www.europeana.eu/rights/rr-f/
000076053 590__ $$a6.97$$b2018
000076053 591__ $$aMATERIALS SCIENCE, MULTIDISCIPLINARY$$b41 / 293 = 0.14$$c2018$$dQ1$$eT1
000076053 591__ $$aNANOSCIENCE & NANOTECHNOLOGY$$b20 / 94 = 0.213$$c2018$$dQ1$$eT1
000076053 591__ $$aCHEMISTRY, MULTIDISCIPLINARY$$b26 / 172 = 0.151$$c2018$$dQ1$$eT1
000076053 591__ $$aPHYSICS, APPLIED$$b18 / 148 = 0.122$$c2018$$dQ1$$eT1
000076053 592__ $$a2.396$$b2018
000076053 593__ $$aNanoscience and Nanotechnology$$c2018$$dQ1
000076053 593__ $$aMaterials Science (miscellaneous)$$c2018$$dQ1
000076053 655_4 $$ainfo:eu-repo/semantics/article$$vinfo:eu-repo/semantics/acceptedVersion
000076053 700__ $$0(orcid)0000-0002-6256-742X$$aOrtiz De Solorzano, Isabel$$uUniversidad de Zaragoza
000076053 700__ $$aPintre, Inmaculada
000076053 700__ $$0(orcid)0000-0002-0595-5514$$aGarcía-Salinas, Sara$$uUniversidad de Zaragoza
000076053 700__ $$0(orcid)0000-0002-6873-5244$$aSebastián, Víctor$$uUniversidad de Zaragoza
000076053 700__ $$0(orcid)0000-0002-6275-1104$$aAndreu, Vanesa
000076053 700__ $$aGimeno, Marina
000076053 700__ $$0(orcid)0000-0003-3165-0156$$aArruebo, Manuel$$uUniversidad de Zaragoza
000076053 7102_ $$15005$$2555$$aUniversidad de Zaragoza$$bDpto. Ing.Quím.Tecnol.Med.Amb.$$cÁrea Ingeniería Química
000076053 773__ $$g10, 6 (2018), 2970-2982$$pNanoscale$$tNANOSCALE$$x2040-3364
000076053 8564_ $$s873870$$uhttps://zaguan.unizar.es/record/76053/files/texto_completo.pdf$$yPostprint
000076053 8564_ $$s116327$$uhttps://zaguan.unizar.es/record/76053/files/texto_completo.jpg?subformat=icon$$xicon$$yPostprint
000076053 909CO $$ooai:zaguan.unizar.es:76053$$particulos$$pdriver
000076053 951__ $$a2020-01-03-14:00:52
000076053 980__ $$aARTICLE