000076058 001__ 76058 000076058 005__ 20220617151026.0 000076058 0247_ $$2doi$$a10.1088/1361-6528/aaa2c1 000076058 0248_ $$2sideral$$a104188 000076058 037__ $$aART-2018-104188 000076058 041__ $$aeng 000076058 100__ $$aRamirez-Nuñez, A.L. 000076058 245__ $$aIn vitro magnetic hyperthermia using polyphenol-coated Fe3O4¿Fe2O3 nanoparticles from Cinnamomun verum and Vanilla planifolia: The concert of green synthesis and therapeutic possibilities 000076058 260__ $$c2018 000076058 5060_ $$aAccess copy available to the general public$$fUnrestricted 000076058 5203_ $$aWe report on a new, environment-friendly synthesis route to produce Fe3O4 magnetic nanoparticles (MNPs) from extracts of the plants Vanilla planifolia and Cinnamomun verum. These aqueous plant extracts have the double function of reducing agents due to their phenolic groups, and also capping materials through the -OH bonding over the MNPs surface. The resulting MNPs have average sizes ˜10-14 nm with a core-shell Fe3O4-¿Fe2O3 structure due to surface oxidation driven by the phenolic groups through OH-covalent bonding. Saturation magnetization values of MS= 70.84 emu g-1 (C. verum) and MS = 59.45 emu g-1 (V. planifolia) are among the largest reported so far from biosynthetic samples. Electron microscopy and infrared spectroscopy data showed a thin organic layer coating the Fe3O4 @¿Fe2O3 MNPs, composed by the phenolic groups from the starting extracts of both C. verum and V. planifolia. A proof of concept for these MNPs as heating agents in magnetic hyperthermia experiments (570 kHz, 23.9 kA m-1) was performed in-vitro, showing their efficacy to induce cell death on BV2 microglial cells after 30 min at a target temperature T = 46 °C. 000076058 536__ $$9info:eu-repo/grantAgreement/ES/MINECO/MAT2016-78201-P 000076058 540__ $$9info:eu-repo/semantics/openAccess$$aby-nc-nd$$uhttp://creativecommons.org/licenses/by-nc-nd/3.0/es/ 000076058 590__ $$a3.399$$b2018 000076058 591__ $$aPHYSICS, APPLIED$$b34 / 148 = 0.23$$c2018$$dQ1$$eT1 000076058 591__ $$aNANOSCIENCE & NANOTECHNOLOGY$$b40 / 94 = 0.426$$c2018$$dQ2$$eT2 000076058 591__ $$aMATERIALS SCIENCE, MULTIDISCIPLINARY$$b83 / 293 = 0.283$$c2018$$dQ2$$eT1 000076058 592__ $$a1.056$$b2018 000076058 593__ $$aBioengineering$$c2018$$dQ1 000076058 593__ $$aChemistry (miscellaneous)$$c2018$$dQ1 000076058 593__ $$aElectrical and Electronic Engineering$$c2018$$dQ1 000076058 593__ $$aNanoscience and Nanotechnology$$c2018$$dQ1 000076058 593__ $$aMechanical Engineering$$c2018$$dQ1 000076058 593__ $$aMechanics of Materials$$c2018$$dQ1 000076058 593__ $$aMaterials Science (miscellaneous)$$c2018$$dQ1 000076058 655_4 $$ainfo:eu-repo/semantics/article$$vinfo:eu-repo/semantics/acceptedVersion 000076058 700__ $$aJimenez-Garcia, L.F. 000076058 700__ $$0(orcid)0000-0003-1558-9279$$aGoya, G.F.$$uUniversidad de Zaragoza 000076058 700__ $$0(orcid)0000-0002-5578-7635$$aSanz, B.$$uUniversidad de Zaragoza 000076058 700__ $$aSantoyo-Salazar, J. 000076058 7102_ $$12003$$2395$$aUniversidad de Zaragoza$$bDpto. Física Materia Condensa.$$cÁrea Física Materia Condensada 000076058 773__ $$g29, 7 (2018), 074001 [18 pp]$$pNanotechnology$$tNanotechnology$$x0957-4484 000076058 8564_ $$s921890$$uhttps://zaguan.unizar.es/record/76058/files/texto_completo.pdf$$yPostprint 000076058 8564_ $$s89911$$uhttps://zaguan.unizar.es/record/76058/files/texto_completo.jpg?subformat=icon$$xicon$$yPostprint 000076058 909CO $$ooai:zaguan.unizar.es:76058$$particulos$$pdriver 000076058 951__ $$a2022-06-17-15:01:35 000076058 980__ $$aARTICLE