New active formulations against M. tuberculosis: Bedaquiline encapsulation in lipid nanoparticles and chitosan nanocapsules

De Matteis, Laura ; Jary, Dorothée ; Lucia Quintana, Ainhoa (Universidad de Zaragoza) ; García-Embid, Sonia ; Serrano-Sevilla, Inés ; Pérez, Daniel ; Aínsa Claver, Jose Antonio (Universidad de Zaragoza) ; Navarro, Fabrice ; Martínez De la Fuente, Jesús (Universidad de Zaragoza)

Resumen: In the last years, the increase in antimicrobial resistance, together with a lack of new drugs for the treatment of bacterial infections resistant to classical antibiotics are of growing concern. Moreover, some of current therapies induce severe side effects and are often difficult to administer. In 2012 the FDA approved the use of bedaquiline, as the first new very effective drug against TB in the last 40¿years. Despite its effectiveness, unfortunately bedaquiline side effects can be so dangerous that at present it is to be prescribed only when no other treatment options are available. The development of effective and safe nanotechnology-based methods can be particularly relevant to increase antimicrobial concentration at the site of infection, to reduce doses in the general circulation, which in turn reduces adverse effects. In this work bedaquiline was encapsulated in two types of nanocarriers, lipid nanoparticles and chitosan-based nanocapsules with high encapsulation efficiency and drug loading values. The efficacy of the drug-encapsulating nanocarriers has been demonstrated in vitro against Mycobacterium tuberculosis, together with the excellent compatibility of both carriers with animal cells. The obtained results open the way for further studies on multi-drug resistant strains of M. tuberculosis and for in vivo studies of the optimized nanocarriers. The promising behaviour of drug-loaded nanocarriers will hopefully lead to a reduction of the administered doses of a quite dangerous drug as bedaquiline, tuning its biodistribution and so decreasing its adverse effects, finally allowing its use in a higher number of patients.

Idioma: Inglés

DOI: 10.1016/j.cej.2017.12.110

Año: 2018

Publicado en: Chemical Engineering Journal 340 (2018), 181-191
ISSN: 1385-8947

Factor impacto JCR: 8.355 (2018)

Categ. JCR: ENGINEERING, ENVIRONMENTAL rank: 2 / 52 = 0.038 (2018) - Q1 - T1
Categ. JCR: ENGINEERING, CHEMICAL rank: 6 / 138 = 0.043 (2018) - Q1 - T1

Factor impacto SCIMAGO: 2.066 - Chemical Engineering (miscellaneous) (Q1) - Chemistry (miscellaneous) (Q1) - Industrial and Manufacturing Engineering (Q1) - Environmental Chemistry (Q1) - Engineering (miscellaneous) (Q4)

Financiación: info:eu-repo/grantAgreement/EC/FP7/604237/EU/Nanotherapeutics for antibiotic resistant emerging bacterial pathogens/NAREB
Financiación: info:eu-repo/grantAgreement/ES/MINECO/SAF2014-54763-C2-2-R

Tipo y forma: Artículo (PostPrint)

Área (Departamento): Área Microbiología (Dpto. Microb.Med.Pr.,Sal.Públ.)
Área (Departamento): Área Química Orgánica (Dpto. Química Orgánica)