000076921 001__ 76921
000076921 005__ 20240111111736.0
000076921 0247_ $$2doi$$a10.17235/reed.2018.5431/2017
000076921 0248_ $$2sideral$$a106895
000076921 037__ $$aART-2018-106895
000076921 041__ $$aeng
000076921 100__ $$aHerrero, J.I.
000076921 245__ $$aPrevalence and progression of chronic kidney disease after a liver transplant: a prospective, real-life, observational, two-year multicenter study
000076921 260__ $$c2018
000076921 5060_ $$aAccess copy available to the general public$$fUnrestricted
000076921 5203_ $$aIntroduction: chronic kidney disease is a frequent complication after liver transplantation. The use of calcineurin inhibitors is one of the causes of this complication. Current immunsuppression regimens that reduce the use of calcineurin inhibitors may be associated with an improved preservation of renal function. Objective: the study aimed to assess the evolution of renal function after liver transplantation in the current routine clinical practice.
Methods: an observational, prospective, multicenter study in adult liver transplant recipients was performed. Two hundred and thirty patients with a good renal function before transplantation were assessed six months post-transplantation (baseline) and every six months until month 30.
Results: at baseline, 32% of the patients had a reduction in the glomerular filtration rate below < 60 ml/min/1.73 m2. The mean glomerular filtration rate increased from 72.3 to 75.6 ml/min/1.73 m2 at baseline and month 30 respectively (p < 0.01). The mean serum creatinine levels (mg/dl) decreased from 1.13 to 1.09 (p < 0.01). The percentage of patients with stage 3 chronic kidney disease decreased from 31.7% to 26.4%, whereas the percentage of patients with stage 4 remained unchanged (0.4% at baseline and 0.5% at month 30). No patients progressed to end-stage kidney disease that required dialysis or renal transplantation.
Conclusion: in the routine clinical practice, a moderate deterioration of renal function is frequent after liver transplantation. However, advanced chronic kidney disease is infrequent in patients with a good pre-transplant renal function.
000076921 540__ $$9info:eu-repo/semantics/openAccess$$aby-nc-nd$$uhttp://creativecommons.org/licenses/by-nc-nd/3.0/es/
000076921 590__ $$a1.858$$b2018
000076921 591__ $$aGASTROENTEROLOGY & HEPATOLOGY$$b70 / 84 = 0.833$$c2018$$dQ4$$eT3
000076921 592__ $$a0.524$$b2018
000076921 593__ $$aMedicine (miscellaneous)$$c2018$$dQ2
000076921 593__ $$aGastroenterology$$c2018$$dQ2
000076921 655_4 $$ainfo:eu-repo/semantics/article$$vinfo:eu-repo/semantics/publishedVersion
000076921 700__ $$aCuervas-Mons, V.
000076921 700__ $$aGómez-Bravo, M.Á.
000076921 700__ $$aFabregat, J.
000076921 700__ $$aOtero, A.
000076921 700__ $$aBilbao, I.
000076921 700__ $$aSalcedo, M.M.
000076921 700__ $$aGonzález-Diéguez, M.L.
000076921 700__ $$aFernández, J.R.
000076921 700__ $$0(orcid)0000-0002-7119-2244$$aSerrano, M.T.$$uUniversidad de Zaragoza
000076921 700__ $$aJiménez, M.
000076921 700__ $$aRodrigo, J.M.
000076921 700__ $$aNarváez, I.
000076921 700__ $$aSánchez, G.
000076921 7102_ $$11007$$2610$$aUniversidad de Zaragoza$$bDpto. Medicina, Psiqu. y Derm.$$cArea Medicina
000076921 773__ $$g110, 9 (2018), 538-543$$pRev. esp. enferm. dig.$$tREVISTA ESPANOLA DE ENFERMEDADES DIGESTIVAS$$x1130-0108
000076921 8564_ $$s626979$$uhttps://zaguan.unizar.es/record/76921/files/texto_completo.pdf$$yVersión publicada
000076921 8564_ $$s113776$$uhttps://zaguan.unizar.es/record/76921/files/texto_completo.jpg?subformat=icon$$xicon$$yVersión publicada
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000076921 951__ $$a2024-01-11-10:59:11
000076921 980__ $$aARTICLE