Native quercetin as a chloride receptor in an organic solvent

Abdi Bellau, M.L. ; Bortolini, O. ; Fantin, G. ; Fogagnolo, M. ; Ragno, D. ; Delso, I. (Universidad de Zaragoza) ; Merino, P. (Universidad de Zaragoza)

Resumen: The binding properties of quercetin toward chloride anions were investigated by means of1H-NMR, 13C-NMR, and electrospray ionization mass spectrometry (ESI-MS) measurements, as well as computational calculations. The results indicate that quercetin behaves primarily as a ditopic receptor with the binding site of the B ring that exhibits stronger chloride affinity compared to the A ring. However, these sites are stronger receptors than those of catechol and resorcinol because of their conjugation with the carbonyl group located on the C ring. The 1:1 and 1:2 complexation of this flavonoid with Cl- was also supported by ESI mass spectrometry.

Idioma: Inglés

DOI: 10.3390/molecules23123366

Año: 2018

Publicado en: Molecules 23, 12 (2018), 3366 [10 pp]
ISSN: 1420-3049

Factor impacto JCR: 3.06 (2018)

Categ. JCR: CHEMISTRY, MULTIDISCIPLINARY rank: 67 / 172 = 0.39 (2018) - Q2 - T2
Categ. JCR: BIOCHEMISTRY & MOLECULAR BIOLOGY rank: 133 / 294 = 0.452 (2018) - Q2 - T2

Factor impacto SCIMAGO: 0.757 - Analytical Chemistry (Q1) - Chemistry (miscellaneous) (Q1) - Drug Discovery (Q1) - Physical and Theoretical Chemistry (Q1) - Molecular Medicine (Q1) - Organic Chemistry (Q1) - Pharmaceutical Science (Q1) - Medicine (miscellaneous) (Q1)

Tipo y forma: Article (Published version)

Área (Departamento): Área Química Orgánica (Dpto. Química Orgánica)