76926 20200217133052.0 doi 10.3390/nu10121959 sideral 109816 ART-2018-109816 eng (orcid)0000-0002-3545-2707 Gargallo-Puyuelo, Carla J. Universidad de Zaragoza Iron treatment may be difficult in inflammatory diseases: Inflammatory bowel disease as a paradigm 2018 Access copy available to the general public Unrestricted Iron plays a key role in many physiological processes; cells need a very exact quantity of iron. In patients with inflammatory bowel disease, anaemia is a unique example of multifactorial origins, frequently being the result of a combination of iron deficiency and anaemia of chronic disease. The main cause of iron deficiency is the activity of the disease. Therefore, the first aim should be to reach complete clinical remission. The iron supplementation route should be determined according to symptoms, severity of anaemia and taking into account comorbidities and individual risks. Oral iron can only be used in patients with mild anaemia, whose disease is inactive and who have not been previously intolerant to oral iron. Intravenous iron should be the first line treatment in patients with moderate-severe anaemia, in patients with active disease, in patients with poor tolerance to oral iron and when erythropoietin agents or a fast response is needed. Erythropoietin is used in a few patients with anaemia to overcome functional iron deficiency, and blood transfusion is being restricted to refractory cases or acute life-threatening situations. info:eu-repo/semantics/openAccess by http://creativecommons.org/licenses/by/3.0/es/ 4.171 2018 NUTRITION & DIETETICS 16 / 86 = 0.186 2018 Q1 T1 1.493 2018 Nutrition and Dietetics 2018 Q1 Food Science 2018 Q1 info:eu-repo/semantics/review info:eu-repo/semantics/publishedVersion Alfambra, Erika García-Erce, José Antonio (orcid)0000-0003-0076-3529 Gomollón, Fernando Universidad de Zaragoza 1007 610 Universidad de Zaragoza Dpto. Medicina, Psiqu. y Derm. Area Medicina 10, 12 (2018), 1959 NUTRIENTS Nutrients 2072-6643 594851 http://zaguan.unizar.es/record/76926/files/texto_completo.pdf Versión publicada 102326 http://zaguan.unizar.es/record/76926/files/texto_completo.jpg?subformat=icon icon Versión publicada oai:zaguan.unizar.es:76926 articulos driver 2020-02-17-12:43:31 ARTICLE