000076931 001__ 76931 000076931 005__ 20200922122725.0 000076931 0247_ $$2doi$$a10.1515/pac-2018-0901 000076931 0248_ $$2sideral$$a109838 000076931 037__ $$aART-2018-109838 000076931 041__ $$aeng 000076931 100__ $$0(orcid)0000-0002-1218-7218$$aFernández-Moreira, V. 000076931 245__ $$aAnticancer properties of gold complexes with biologically relevant ligands 000076931 260__ $$c2018 000076931 5060_ $$aAccess copy available to the general public$$fUnrestricted 000076931 5203_ $$aThe present review highlights our findings in the field of antitumor gold complexes bearing biologically relevant molecules, such as DNA-bases, amino acids or peptide derivatives. The results show that very active complexes are achieved with this sort of ligands in several cancer cells. In these compounds the gold center is bonded to these biological molecules mainly through a sulfur atom belonging to a cysteine moiety or to a thionicotinic moiety as result of the functionalization of the biological compounds, and additionally phosphines or N-heterocyclic carbenes are present as ancillary ligands. These robust compounds are stable in the biological media and can be transported to their targets without previous deactivation. The presence of these scaffolds represents a good approach to obtain complexes with improved biologically activity, better transport and biodistribution to cancer cells. Thioredoxin reductase (TrxR) has been shown as the main target for these complexes and in some cases, DNA interactions has been also observed. 000076931 536__ $$9info:eu-repo/grantAgreement/ES/DGA/FSE$$9info:eu-repo/grantAgreement/ES/MINECO/CTQ2016-75816-C2-1-P$$9info:eu-repo/grantAgreement/ES/MINECO/CTQ2017-88091-P 000076931 540__ $$9info:eu-repo/semantics/openAccess$$aby-nc-nd$$uhttp://creativecommons.org/licenses/by-nc-nd/3.0/es/ 000076931 590__ $$a2.35$$b2018 000076931 591__ $$aCHEMISTRY, MULTIDISCIPLINARY$$b82 / 172 = 0.477$$c2018$$dQ2$$eT2 000076931 592__ $$a1.24$$b2018 000076931 593__ $$aChemistry (miscellaneous)$$c2018$$dQ1 000076931 593__ $$aChemical Engineering (miscellaneous)$$c2018$$dQ1 000076931 655_4 $$ainfo:eu-repo/semantics/article$$vinfo:eu-repo/semantics/publishedVersion 000076931 700__ $$0(orcid)0000-0002-5244-9569$$aPerez Herrera, R.$$uUniversidad de Zaragoza 000076931 700__ $$0(orcid)0000-0003-0553-0695$$aGimeno, M.C.$$uUniversidad de Zaragoza 000076931 7102_ $$12010$$2760$$aUniversidad de Zaragoza$$bDpto. Química Inorgánica$$cÁrea Química Inorgánica 000076931 7102_ $$12013$$2765$$aUniversidad de Zaragoza$$bDpto. Química Orgánica$$cÁrea Química Orgánica 000076931 773__ $$g91, 2 (2018), 247 – 269$$pPure appl. chem.$$tPURE AND APPLIED CHEMISTRY$$x0033-4545 000076931 8564_ $$s452233$$uhttps://zaguan.unizar.es/record/76931/files/texto_completo.pdf$$yVersión publicada 000076931 8564_ $$s104977$$uhttps://zaguan.unizar.es/record/76931/files/texto_completo.jpg?subformat=icon$$xicon$$yVersión publicada 000076931 909CO $$ooai:zaguan.unizar.es:76931$$particulos$$pdriver 000076931 951__ $$a2020-09-22-12:20:03 000076931 980__ $$aARTICLE