000076945 001__ 76945
000076945 005__ 20211216131132.0
000076945 0247_ $$2doi$$a10.1186/s13071-018-3231-8
000076945 0248_ $$2sideral$$a109757
000076945 037__ $$aART-2018-109757
000076945 041__ $$aeng
000076945 100__ $$aGomez, S.A.
000076945 245__ $$aA randomized, blinded, controlled trial to assess sand fly mortality of fluralaner administered orally in dogs
000076945 260__ $$c2018
000076945 5060_ $$aAccess copy available to the general public$$fUnrestricted
000076945 5203_ $$aBackground: Leishmania infantum is the parasite responsible for the disease in humans known as zoonotic visceral leishmaniasis (ZVL). Dogs are considered the main domestic reservoir of ZVL and sand flies are the proven vectors. The use of systemic insecticides in dogs has been studied as an alternative strategy to control ZVL in endemic areas. One systemic insecticide in dogs, fluralaner, has a proven anti-sand fly effect in membrane-fed studies. However, the efficacy and duration on sand flies directly feeding from dogs treated with fluralaner remains unknown.
Methods: Direct feeding bioassays were performed on 10 beagle dogs that had been randomly assigned to two groups: one with five dogs orally treated with Bravecto® (fluralaner) and other five as a control. About 30 females of Phlebotomus papatasi were allowed to directly feed from dogs at seven days before the administration of the treatment and Days 3, 17, 31, 45 and 73 post-treatment. Sand fly mortality after feeding was observed every 24 h for 5 days. The Kaplan-Meyer method, Henderson-Tilton formula and a negative binomial mixed model were used to respectively calculate: (i) mortality and its 95% confidence interval (CI); (ii) efficacy of the insecticide at killing sand flies in 24 h; and (iii) differences in the risk of sand fly death at 24 h after feeding.
Results: Control sand fly mortality 24 h after feeding was always = 20% and mortality in the fluralaner group ranged from 2% (95% CI: 0-4%) 7 days before treatment to 100% at 3 days post-treatment. Fluralaner efficacy was 100, 93, 94 and 75% at Days 3, 17, 31 and 45, respectively (P < 0.0001). The increase in the risk of sand fly death was 32.9 (95% CI: 4-263), 76 (95% CI: 8-705), 95.8 (95% CI: 9-1029) and 10.6 times (95% CI: 1.43-79) on Days 3, 17, 31 and 45, respectively
Conclusions: The efficacy of fluralaner, orally administered to dogs, against sand-flies was above 90% for 31 days. Fluralaner administered to dogs should be further evaluated as a control strategy in ZVL endemic areas.
000076945 536__ $$9This project has received funding from the European Union’s Horizon 2020 research and innovation program under grant agreement No H2020 642609-EUROLEISH-NET$$9info:eu-repo/grantAgreement/EC/H2020/642609/EU/Control of leishmaniasis, from bench to bedside and community/EUROLEISH-NET
000076945 540__ $$9info:eu-repo/semantics/openAccess$$aby$$uhttp://creativecommons.org/licenses/by/3.0/es/
000076945 590__ $$a3.031$$b2018
000076945 591__ $$aTROPICAL MEDICINE$$b2 / 21 = 0.095$$c2018$$dQ1$$eT1
000076945 591__ $$aPARASITOLOGY$$b7 / 36 = 0.194$$c2018$$dQ1$$eT1
000076945 592__ $$a1.565$$b2018
000076945 593__ $$aParasitology$$c2018$$dQ1
000076945 593__ $$aInfectious Diseases$$c2018$$dQ1
000076945 655_4 $$ainfo:eu-repo/semantics/article$$vinfo:eu-repo/semantics/publishedVersion
000076945 700__ $$0(orcid)0000-0003-0663-8411$$aLucientes, J.$$uUniversidad de Zaragoza
000076945 700__ $$0(orcid)0000-0002-2048-4749$$aCastillo, J.A.$$uUniversidad de Zaragoza
000076945 700__ $$0(orcid)0000-0001-5750-3643$$aPeris, M.P.$$uUniversidad de Zaragoza
000076945 700__ $$0(orcid)0000-0001-7046-2997$$aDelacour, S.$$uUniversidad de Zaragoza
000076945 700__ $$0(orcid)0000-0001-7331-2863$$aOrtega, P.$$uUniversidad de Zaragoza
000076945 700__ $$aOropeza, R.V.$$uUniversidad de Zaragoza
000076945 700__ $$aPicado, A.
000076945 7102_ $$11009$$2773$$aUniversidad de Zaragoza$$bDpto. Patología Animal$$cÁrea Sanidad Animal
000076945 773__ $$g11, 1 (2018), 627 [6 pp]$$pParasites & Vectors$$tParasites and Vectors$$x1756-3305
000076945 8564_ $$s423140$$uhttps://zaguan.unizar.es/record/76945/files/texto_completo.pdf$$yVersión publicada
000076945 8564_ $$s103200$$uhttps://zaguan.unizar.es/record/76945/files/texto_completo.jpg?subformat=icon$$xicon$$yVersión publicada
000076945 909CO $$ooai:zaguan.unizar.es:76945$$particulos$$pdriver
000076945 951__ $$a2021-12-16-13:02:11
000076945 980__ $$aARTICLE