000076976 001__ 76976
000076976 005__ 20200117221625.0
000076976 0247_ $$2doi$$a10.1038/s41598-018-35243-4
000076976 0248_ $$2sideral$$a109867
000076976 037__ $$aART-2018-109867
000076976 041__ $$aeng
000076976 100__ $$aMoen, A.E.F.
000076976 245__ $$aThe prevalence and transcriptional activity of the mucosal microbiota of ulcerative colitis patients
000076976 260__ $$c2018
000076976 5060_ $$aAccess copy available to the general public$$fUnrestricted
000076976 5203_ $$aActive microbes likely have larger impact on gut health status compared to inactive or dormant microbes. We investigate the composition of active and total mucosal microbiota of treatment-naïve ulcerative colitis (UC) patients to determine the microbial picture at the start-up phase of disease, using both a 16S rRNA transcript and gene amplicon sequencing. DNA and RNA were isolated from the same mucosal colonic biopsies. Our aim was to identify active microbial members of the microbiota in early stages of disease and reveal which members are present, but do not act as major players. We demonstrated differences in active and total microbiota of UC patients when comparing inflamed to non-inflamed tissue. Several taxa, among them the Proteobacteria phyla and families therein, revealed lower transcriptional activity despite a high presence. The Bifidobacteriaceae family of the Actinobacteria phylum showed lower abundance in the active microbiota, although no difference in presence was detected. The most abundant microbiota members of the inflamed tissue in UC patients were not the most active. Knowledge of active members of microbiota in UC patients could enhance our understanding of disease etiology. The active microbial community composition did not deviate from the total when comparing UC patients to non-IBD controls.
000076976 536__ $$9info:eu-repo/grantAgreement/EC/FP7/305676/EU/Inflammatory Bowel Disease CHARACTERization by a multi-modal integrated biomarker study/IBD-CHARACTER
000076976 540__ $$9info:eu-repo/semantics/openAccess$$aby$$uhttp://creativecommons.org/licenses/by/3.0/es/
000076976 590__ $$a4.011$$b2018
000076976 591__ $$aMULTIDISCIPLINARY SCIENCES$$b14 / 69 = 0.203$$c2018$$dQ1$$eT1
000076976 592__ $$a1.414$$b2018
000076976 593__ $$aMultidisciplinary$$c2018$$dQ1
000076976 655_4 $$ainfo:eu-repo/semantics/article$$vinfo:eu-repo/semantics/publishedVersion
000076976 700__ $$aLindstrøm, J.C.
000076976 700__ $$aTannæs, T.M.
000076976 700__ $$aVatn, S.
000076976 700__ $$aRicanek, P.
000076976 700__ $$aVatn, M.H.
000076976 700__ $$aJahnsen, J.
000076976 700__ $$aFrengen, A.B.
000076976 700__ $$aDahl, F.A.
000076976 700__ $$aYou, P.
000076976 700__ $$aSølvernes, J.
000076976 700__ $$aEkeland, G.S.
000076976 700__ $$aDetlie, T.E.
000076976 700__ $$aOlbjørn, C.
000076976 700__ $$aO’Leary, K.R.
000076976 700__ $$aVentham, N.T.
000076976 700__ $$aKennedy, N.A.
000076976 700__ $$aKalla, R.
000076976 700__ $$aAdams, A.
000076976 700__ $$aDrummond, H.E.
000076976 700__ $$aBoyapati, R.
000076976 700__ $$aNimmo, E.R.
000076976 700__ $$aWilson, D.C.
000076976 700__ $$aSatsangi, J.
000076976 700__ $$aHeath, S.C.
000076976 700__ $$aGut, M.
000076976 700__ $$aMerkel, A.
000076976 700__ $$aBayes, M.
000076976 700__ $$aGut, I.G.
000076976 700__ $$aKeita, Å.V.
000076976 700__ $$aSöderholm, J.D.
000076976 700__ $$aHjortswang, H.
000076976 700__ $$aCarstens, A.
000076976 700__ $$aBergemalm, D.
000076976 700__ $$aHalfvarson, J.
000076976 700__ $$aAndersson, E.
000076976 700__ $$aLindqvist, M.
000076976 700__ $$aRepsilber, D.
000076976 700__ $$aPierik, M.
000076976 700__ $$aJonkers, D.
000076976 700__ $$aGomollón, F.
000076976 700__ $$aD’Amato, M.
000076976 700__ $$aTörkvist, L.
000076976 700__ $$aHjelm, F.
000076976 700__ $$aGullberg, M.
000076976 700__ $$aNordberg, N.
000076976 700__ $$aOcklind, A.
000076976 700__ $$aPettersson, E.
000076976 700__ $$aEkman, D.
000076976 700__ $$aSundell, M.
000076976 700__ $$aModig, E.
000076976 700__ $$aBonfiglio, F.
000076976 700__ $$aVeillard, A.C.
000076976 700__ $$aSchoemans, R.
000076976 700__ $$0(orcid)0000-0003-0076-3529$$aPoncelet, D.$$uUniversidad de Zaragoza
000076976 700__ $$aSabatel, C.
000076976 700__ $$aLindahl, T.
000076976 700__ $$aCiemniejewska, E.
000076976 700__ $$aCasén, C.
000076976 700__ $$aLees, C.
000076976 700__ $$aNoble, C.L.
000076976 700__ $$aArnott, I.
000076976 700__ $$aHo, G.T.
000076976 700__ $$aShand, A.G.
000076976 700__ $$aThe, IBD-Character, Consortium
000076976 7102_ $$11007$$2610$$aUniversidad de Zaragoza$$bDpto. Medicina, Psiqu. y Derm.$$cArea Medicina
000076976 773__ $$g8, 1 (2018), 17278 [12 pp]$$pSci. rep.$$tSCIENTIFIC REPORTS$$x2045-2322
000076976 8564_ $$s1722718$$uhttps://zaguan.unizar.es/record/76976/files/texto_completo.pdf$$yVersión publicada
000076976 8564_ $$s110918$$uhttps://zaguan.unizar.es/record/76976/files/texto_completo.jpg?subformat=icon$$xicon$$yVersión publicada
000076976 909CO $$ooai:zaguan.unizar.es:76976$$particulos$$pdriver
000076976 951__ $$a2020-01-17-21:56:40
000076976 980__ $$aARTICLE