doi:10.1371/journal.pone.0210752engRando, A.de la Torre, M.Martinez-Muriana, A.Zaragoza, P.Musaro, A.Hernández, S.Navarro, X.Toivonen, J.M.Osta, R.Chemotherapeutic agent 5-fluorouracil increases survival of SOD1 mouse model of ALSART-2019-109675Amyotrophic lateral sclerosis (ALS) is a lethal motor neuron disease with no cure. Currently there are only two ALS drugs approved by the FDA, both with a limited therapeutic effect. In the search for drug candidates for ALS, we studied the effect of known stem cell mobilizing agents (treatment) and antimetabolite 5-fluorouracil (5-FU) (anti-treatment) in SOD1G93A model of ALS. Surprisingly, we found that anti-cancer drug 5-FU increases lifespan, delays the disease onset and improves motor performance in ALS mice. Although we were not able to demonstrate the mechanistic basis of the beneficial 5-FU action in ALS mice, our findings suggest that 5-FU or similar drugs are possible drug candidates for the treatment of motor neuron diseases through drug repurposing.2019http://zaguan.unizar.es/record/7699010.1371/journal.pone.0210752http://zaguan.unizar.es/record/76990oai:zaguan.unizar.es:76990info:eu-repo/grantAgreement/ES/FIS/PI14-00947info:eu-repo/grantAgreement/ES/FIS/PI17-00949info:eu-repo/grantAgreement/ES/ISCIII/CB06-05-1105info:eu-repo/grantAgreement/ES/ISCIII/RD12-0019-0011info:eu-repo/grantAgreement/ES/ISCIII/RD16-0011-0035PLoS ONE 14, 1 (2019), e0210752 [16pp]byhttp://creativecommons.org/licenses/by/3.0/es/info:eu-repo/semantics/openAccess