76990 20240104111810.0 doi 10.1371/journal.pone.0210752 sideral 109675 ART-2019-109675 eng Rando, A. (orcid)0000-0002-2898-4561 Chemotherapeutic agent 5-fluorouracil increases survival of SOD1 mouse model of ALS 2019 Access copy available to the general public Unrestricted Amyotrophic lateral sclerosis (ALS) is a lethal motor neuron disease with no cure. Currently there are only two ALS drugs approved by the FDA, both with a limited therapeutic effect. In the search for drug candidates for ALS, we studied the effect of known stem cell mobilizing agents (treatment) and antimetabolite 5-fluorouracil (5-FU) (anti-treatment) in SOD1G93A model of ALS. Surprisingly, we found that anti-cancer drug 5-FU increases lifespan, delays the disease onset and improves motor performance in ALS mice. Although we were not able to demonstrate the mechanistic basis of the beneficial 5-FU action in ALS mice, our findings suggest that 5-FU or similar drugs are possible drug candidates for the treatment of motor neuron diseases through drug repurposing. info:eu-repo/grantAgreement/ES/FIS/PI14-00947 info:eu-repo/grantAgreement/ES/FIS/PI17-00949 info:eu-repo/grantAgreement/ES/ISCIII/CB06-05-1105 info:eu-repo/grantAgreement/ES/ISCIII/RD12-0019-0011 info:eu-repo/grantAgreement/ES/ISCIII/RD16-0011-0035 info:eu-repo/semantics/openAccess by http://creativecommons.org/licenses/by/3.0/es/ 2.74 2019 MULTIDISCIPLINARY SCIENCES 27 / 71 = 0.38 2019 Q2 T2 1.023 2019 Multidisciplinary 2019 Q1 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion de la Torre, M. Universidad de Zaragoza (orcid)0000-0002-7955-7164 Martinez-Muriana, A. Zaragoza, P. Universidad de Zaragoza (orcid)0000-0001-5740-0185 Musaro, A. Hernández, S. Navarro, X. Toivonen, J.M. Universidad de Zaragoza (orcid)0000-0002-7243-1737 Osta, R. Universidad de Zaragoza (orcid)0000-0001-5687-6704 1001 420 Universidad de Zaragoza Dpto. Anatom.,Embri.Genét.Ani. Área Genética 14, 1 (2019), e0210752 [16pp] PLoS One PLoS ONE 1932-6203 1970540 http://zaguan.unizar.es/record/76990/files/texto_completo.pdf Versión publicada 101892 http://zaguan.unizar.es/record/76990/files/texto_completo.jpg?subformat=icon icon Versión publicada oai:zaguan.unizar.es:76990 articulos driver 2024-01-04-11:02:08 ARTICLE