000077200 001__ 77200
000077200 005__ 20200117221627.0
000077200 0247_ $$2doi$$a10.1038/s41408-018-0153-9
000077200 0248_ $$2sideral$$a110472
000077200 037__ $$aART-2018-110472
000077200 041__ $$aeng
000077200 100__ $$aSanoja-Flores, L.
000077200 245__ $$aNext generation flow for minimally-invasive blood characterization of MGUS and multiple myeloma at diagnosis based on circulating tumor plasma cells (CTPC)
000077200 260__ $$c2018
000077200 5060_ $$aAccess copy available to the general public$$fUnrestricted
000077200 5203_ $$aHere, we investigated for the first time the frequency and number of circulating tumor plasma cells (CTPC) in peripheral blood (PB) of newly diagnosed patients with localized and systemic plasma cell neoplasms (PCN) using next-generation flow cytometry (NGF) and correlated our findings with the distinct diagnostic and prognostic categories of the disease. Overall, 508 samples from 264 newly diagnosed PCN patients, were studied. CTPC were detected in PB of all active multiple myeloma (MM; 100%), and smoldering MM (SMM) patients (100%), and in more than half (59%) monoclonal gammopathy of undetermined significance (MGUS) cases (p < 0.0001); in contrast, CTPC were present in a small fraction of solitary plasmacytoma patients (18%). Higher numbers of CTPC in PB were associated with higher levels of BM infiltration and more adverse prognostic features, together with shorter time to progression from MGUS to MM (p < 0.0001) and a shorter survival in MM patients with active disease requiring treatment (p <= 0.03). In summary, the presence of CTPC in PB as assessed by NGF at diagnosis, emerges as a hallmark of disseminated PCN, higher numbers of PB CTPC being strongly associated with a malignant disease behavior and a poorer outcome of both MGUS and MM.
000077200 536__ $$9info:eu-repo/grantAgreement/ES/MINECO-FEDER/ISCIII-CB16-12-00233$$9info:eu-repo/grantAgreement/ES/MINECO-FEDER/ISCIII-CB16-12-00369$$9info:eu-repo/grantAgreement/ES/MINECO-FEDER/ISCIII-CB16-12-00400$$9info:eu-repo/grantAgreement/ES/MINECO-FEDER/ISCIII-CB16-12-00489$$9info:eu-repo/grantAgreement/ES/MINECO-ISCIII/DTS15-00119
000077200 540__ $$9info:eu-repo/semantics/openAccess$$aby$$uhttp://creativecommons.org/licenses/by/3.0/es/
000077200 590__ $$a7.895$$b2018
000077200 591__ $$aONCOLOGY$$b23 / 229 = 0.1$$c2018$$dQ1$$eT1
000077200 591__ $$aHEMATOLOGY$$b6 / 73 = 0.082$$c2018$$dQ1$$eT1
000077200 592__ $$a2.82$$b2018
000077200 593__ $$aOncology$$c2018$$dQ1
000077200 593__ $$aHematology$$c2018$$dQ1
000077200 655_4 $$ainfo:eu-repo/semantics/article$$vinfo:eu-repo/semantics/publishedVersion
000077200 700__ $$aFlores-Montero, J.
000077200 700__ $$aGarces, J.J.
000077200 700__ $$aPaiva, B.
000077200 700__ $$aPuig, N.
000077200 700__ $$aGarcia-Mateo, A.
000077200 700__ $$aGarcia-Sanchez, O.
000077200 700__ $$aCorral-Mateos, A.
000077200 700__ $$aBurgos, L.
000077200 700__ $$aBlanco, E.
000077200 700__ $$aHernandez-Martin, J.
000077200 700__ $$aPontes, R.
000077200 700__ $$aDiez-Campelo, M.
000077200 700__ $$aMillacoy, P.
000077200 700__ $$aRodriguez-Otero, P.
000077200 700__ $$aProsper, F.
000077200 700__ $$aMerino, J.
000077200 700__ $$aVidriales, M.B.
000077200 700__ $$aGarcia-Sanz, R.
000077200 700__ $$aRomero, A.
000077200 700__ $$0(orcid)0000-0001-8515-3599$$aPalomera, L.$$uUniversidad de Zaragoza
000077200 700__ $$aRios-Tamayo, R.
000077200 700__ $$aPerez-Andres, M.
000077200 700__ $$aBlanco, J.F.
000077200 700__ $$aGonzalez, M.
000077200 700__ $$avan Dongen, J.J.M.
000077200 700__ $$aDurie, B.
000077200 700__ $$aMateos, M.V.
000077200 700__ $$aSan-Miguel, J.
000077200 700__ $$aOrfao, A.
000077200 7102_ $$11007$$2610$$aUniversidad de Zaragoza$$bDpto. Medicina, Psiqu. y Derm.$$cArea Medicina
000077200 773__ $$g8 (2018), 117 [11 pp]$$pBLOOD CANCER JOURNAL$$tBLOOD CANCER JOURNAL$$x2044-5385
000077200 8564_ $$s417740$$uhttps://zaguan.unizar.es/record/77200/files/texto_completo.pdf$$yVersión publicada
000077200 8564_ $$s100383$$uhttps://zaguan.unizar.es/record/77200/files/texto_completo.jpg?subformat=icon$$xicon$$yVersión publicada
000077200 909CO $$ooai:zaguan.unizar.es:77200$$particulos$$pdriver
000077200 951__ $$a2020-01-17-21:58:05
000077200 980__ $$aARTICLE