000078020 001__ 78020
000078020 005__ 20201007082611.0
000078020 0247_ $$2doi$$a10.2217/nnm-2018-0258
000078020 0248_ $$2sideral$$a110570
000078020 037__ $$aART-2019-110570
000078020 041__ $$aeng
000078020 100__ $$0(orcid)0000-0002-6275-1104$$aAndreu, Vanesa
000078020 245__ $$aMatryoshka-type gastro-resistant microparticles for the oral treatment of Mycobacterium tuberculosis
000078020 260__ $$c2019
000078020 5060_ $$aAccess copy available to the general public$$fUnrestricted
000078020 5203_ $$aAim: Production of Matryoshka-type gastroresistant microparticles containing antibiotic-loaded poly lactic-co-glycolic acid (PLGA) nanoparticles (NP) against Mycobacterium tuberculosis. Materials & methods: The emulsification and evaporation methods were followed for the synthesis of PLGA–NPs and methacrylic acid-ethyl acrylate-based coatings to protect rifampicin from degradation under simulated gastric conditions. Results & conclusion: The inner antibiotic-loaded NPs here reported can be released under simulated intestinal conditions whereas their coating protects them from degradation under simulated gastric conditions. The encapsulation does not hinder the antituberculosis action of the encapsulated antibiotic rifampicin. A sustained antibiotic release could be obtained when using the drug-loaded encapsulated NPs. Compared with the administration of the free drug, a more effective elimination of M. tuberculosis was observed when applying the NPs against infected macrophages. The antibiotic-loaded PLGA–NPs were also able to cross an in vitro model of intestinal barrier. Matryoshka-type gastroresistant microparticles containing antibiotic-loaded poly lactic-co-glycolic acid nanoparticles against M. tuberculosis were produced to protect the antibiotic from degradation under simulated gastric conditions. The antibiotic-loaded poly lactic-co-glycolic acid nanoparticles were able to cross an in vitro model of intestinal barrier, being more effective in the elimination of M. tuberculosis when applied against infected macrophages compared with the use of the free drug.
000078020 536__ $$9info:eu-repo/grantAgreement/ES/MEC/FPU14-01854$$9info:eu-repo/grantAgreement/ES/ISCIII/PI16-01912$$9info:eu-repo/grantAgreement/ES/ISCIII/PI13-01546$$9info:eu-repo/grantAgreement/EC/FP7/614715/EU/A Photo-triggered On-demand Drug Delivery System for Chronic Pain/NANOHEDONISM
000078020 540__ $$9info:eu-repo/semantics/openAccess$$aAll rights reserved$$uhttp://www.europeana.eu/rights/rr-f/
000078020 590__ $$a4.3$$b2019
000078020 591__ $$aBIOTECHNOLOGY & APPLIED MICROBIOLOGY$$b29 / 156 = 0.186$$c2019$$dQ1$$eT1
000078020 591__ $$aNANOSCIENCE & NANOTECHNOLOGY$$b43 / 103 = 0.417$$c2019$$dQ2$$eT2
000078020 592__ $$a0.997$$b2019
000078020 593__ $$aDevelopment$$c2019$$dQ1
000078020 593__ $$aMedicine (miscellaneous)$$c2019$$dQ1
000078020 593__ $$aBiomedical Engineering$$c2019$$dQ1
000078020 593__ $$aMaterials Science (miscellaneous)$$c2019$$dQ1
000078020 593__ $$aNanoscience and Nanotechnology$$c2019$$dQ2
000078020 593__ $$aBioengineering$$c2019$$dQ2
000078020 655_4 $$ainfo:eu-repo/semantics/article$$vinfo:eu-repo/semantics/acceptedVersion
000078020 700__ $$0(orcid)0000-0002-6277-7996$$aLarrea, Ane
000078020 700__ $$aRodriguez-Fernandez, Pablo
000078020 700__ $$aAlfaro, Salvador
000078020 700__ $$aGracia, Begoña$$uUniversidad de Zaragoza
000078020 700__ $$0(orcid)0000-0002-0111-4697$$aLucía, Ainhoa$$uUniversidad de Zaragoza
000078020 700__ $$0(orcid)0000-0002-4678-7465$$aUsón, Laura$$uUniversidad de Zaragoza
000078020 700__ $$aGómez, Andromeda-Celeste
000078020 700__ $$0(orcid)0000-0003-2293-363X$$aMendoza, Gracia$$uUniversidad de Zaragoza
000078020 700__ $$aLacoma, Alicia
000078020 700__ $$aDomínguez, José
000078020 700__ $$aPrat, Cristina
000078020 700__ $$0(orcid)0000-0002-6873-5244$$aSebastián, Victor$$uUniversidad de Zaragoza
000078020 700__ $$0(orcid)0000-0003-2076-844X$$aAinsa, José Antonio$$uUniversidad de Zaragoza
000078020 700__ $$0(orcid)0000-0003-3165-0156$$aArruebo, Manuel$$uUniversidad de Zaragoza
000078020 7102_ $$11008$$2630$$aUniversidad de Zaragoza$$bDpto. Microb.Med.Pr.,Sal.Públ.$$cÁrea Microbiología
000078020 7102_ $$15005$$2555$$aUniversidad de Zaragoza$$bDpto. Ing.Quím.Tecnol.Med.Amb.$$cÁrea Ingeniería Química
000078020 7102_ $$11008$$2X$$aUniversidad de Zaragoza$$bDpto. Microb.Med.Pr.,Sal.Públ.$$cProy. investigación HQA
000078020 773__ $$g14, 6 (2019), 707-726$$pNanomedicine$$tNanomedicine$$x1743-5889
000078020 8564_ $$s990296$$uhttps://zaguan.unizar.es/record/78020/files/texto_completo.pdf$$yPostprint
000078020 8564_ $$s101486$$uhttps://zaguan.unizar.es/record/78020/files/texto_completo.jpg?subformat=icon$$xicon$$yPostprint
000078020 909CO $$ooai:zaguan.unizar.es:78020$$particulos$$pdriver
000078020 951__ $$a2020-10-07-08:20:56
000078020 980__ $$aARTICLE