000078022 001__ 78022
000078022 005__ 20210121114536.0
000078022 0247_ $$2doi$$a10.1016/j.snb.2019.02.110
000078022 0248_ $$2sideral$$a110594
000078022 037__ $$aART-2019-110594
000078022 041__ $$aeng
000078022 100__ $$0(orcid)0000-0001-9595-0831$$aMalankowska, M.$$uUniversidad de Zaragoza
000078022 245__ $$aUnderstanding blood oxygenation in a microfluidic meander double side membrane contactor
000078022 260__ $$c2019
000078022 5060_ $$aAccess copy available to the general public$$fUnrestricted
000078022 5203_ $$aLung disease is one of the most important causes of high morbidity in preterm infants. In this work, we study a simple and easy to fabricate microfluidic device that demonstrates a great potential for blood oxygenation. A meander type architecture with double side vertical membrane arrangement has been selected as reference model to investigate the oxygenation process. The design criteria for the fabricated devices has been to maximize the oxygen saturation level while ensuring the physiological blood flow in order to avoid thrombus formation and channel blockage during operation. A mathematical model for the oxygen transfer has been developed and validated by the experimental study. The obtained results demonstrate that blood was successfully oxygenated up to approximately 98% of O2 saturation and that the oxygen transfer rate at 1 mL/min blood flow rate was approximately 92 mL/min·m2. Finally, a sensitivity analysis of the key parameters, i.e. size of the channel, oxygen concentration in the gas phase and oxygen permeation properties of the membrane, is carried out to discuss the performance limits and to settle the guidelines for future developments.
000078022 536__ $$9info:eu-repo/grantAgreement/ES/DGA/EU-EACEA/FPA2011-0014$$9info:eu-repo/grantAgreement/ES/DGA/EU-EACEA/SGA2012-1719$$9info:eu-repo/grantAgreement/ES/ISCIII/CIBER-BBN
000078022 540__ $$9info:eu-repo/semantics/openAccess$$aby-nc-nd$$uhttp://creativecommons.org/licenses/by-nc-nd/3.0/es/
000078022 590__ $$a7.1$$b2019
000078022 591__ $$aCHEMISTRY, ANALYTICAL$$b4 / 86 = 0.047$$c2019$$dQ1$$eT1
000078022 591__ $$aINSTRUMENTS & INSTRUMENTATION$$b2 / 64 = 0.031$$c2019$$dQ1$$eT1
000078022 591__ $$aELECTROCHEMISTRY$$b4 / 27 = 0.148$$c2019$$dQ1$$eT1
000078022 592__ $$a1.625$$b2019
000078022 593__ $$aCondensed Matter Physics$$c2019$$dQ1
000078022 593__ $$aElectrical and Electronic Engineering$$c2019$$dQ1
000078022 593__ $$aElectronic, Optical and Magnetic Materials$$c2019$$dQ1
000078022 593__ $$aSurfaces, Coatings and Films$$c2019$$dQ1
000078022 593__ $$aMaterials Chemistry$$c2019$$dQ1
000078022 593__ $$aMetals and Alloys$$c2019$$dQ1
000078022 593__ $$aInstrumentation$$c2019$$dQ1
000078022 655_4 $$ainfo:eu-repo/semantics/article$$vinfo:eu-repo/semantics/acceptedVersion
000078022 700__ $$0(orcid)0000-0003-3211-0485$$aJulian, I.
000078022 700__ $$0(orcid)0000-0002-8448-7543$$aPellejero, I.
000078022 700__ $$aRho, H.S.
000078022 700__ $$aSchlautmann, S.
000078022 700__ $$aTiggelaar, R.M.
000078022 700__ $$0(orcid)0000-0001-9897-6527$$aPina, M.P.$$uUniversidad de Zaragoza
000078022 700__ $$aGardeniers, H.J.G.E.
000078022 700__ $$0(orcid)0000-0002-4758-9380$$aMallada, R.$$uUniversidad de Zaragoza
000078022 7102_ $$15005$$2555$$aUniversidad de Zaragoza$$bDpto. Ing.Quím.Tecnol.Med.Amb.$$cÁrea Ingeniería Química
000078022 773__ $$g288, 1 (2019), 414-424$$pSens. actuators, B, Chem.$$tSENSORS AND ACTUATORS B-CHEMICAL$$x0925-4005
000078022 8564_ $$s713643$$uhttps://zaguan.unizar.es/record/78022/files/texto_completo.pdf$$yPostprint
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000078022 951__ $$a2021-01-21-11:13:57
000078022 980__ $$aARTICLE