78022 20210121114536.0 doi 10.1016/j.snb.2019.02.110 sideral 110594 ART-2019-110594 eng (orcid)0000-0001-9595-0831 Malankowska, M. Universidad de Zaragoza Understanding blood oxygenation in a microfluidic meander double side membrane contactor 2019 Access copy available to the general public Unrestricted Lung disease is one of the most important causes of high morbidity in preterm infants. In this work, we study a simple and easy to fabricate microfluidic device that demonstrates a great potential for blood oxygenation. A meander type architecture with double side vertical membrane arrangement has been selected as reference model to investigate the oxygenation process. The design criteria for the fabricated devices has been to maximize the oxygen saturation level while ensuring the physiological blood flow in order to avoid thrombus formation and channel blockage during operation. A mathematical model for the oxygen transfer has been developed and validated by the experimental study. The obtained results demonstrate that blood was successfully oxygenated up to approximately 98% of O2 saturation and that the oxygen transfer rate at 1 mL/min blood flow rate was approximately 92 mL/min·m2. Finally, a sensitivity analysis of the key parameters, i.e. size of the channel, oxygen concentration in the gas phase and oxygen permeation properties of the membrane, is carried out to discuss the performance limits and to settle the guidelines for future developments. info:eu-repo/grantAgreement/ES/DGA/EU-EACEA/FPA2011-0014 info:eu-repo/grantAgreement/ES/DGA/EU-EACEA/SGA2012-1719 info:eu-repo/grantAgreement/ES/ISCIII/CIBER-BBN info:eu-repo/semantics/openAccess by-nc-nd http://creativecommons.org/licenses/by-nc-nd/3.0/es/ 7.1 2019 CHEMISTRY, ANALYTICAL 4 / 86 = 0.047 2019 Q1 T1 INSTRUMENTS & INSTRUMENTATION 2 / 64 = 0.031 2019 Q1 T1 ELECTROCHEMISTRY 4 / 27 = 0.148 2019 Q1 T1 1.625 2019 Condensed Matter Physics 2019 Q1 Electrical and Electronic Engineering 2019 Q1 Electronic, Optical and Magnetic Materials 2019 Q1 Surfaces, Coatings and Films 2019 Q1 Materials Chemistry 2019 Q1 Metals and Alloys 2019 Q1 Instrumentation 2019 Q1 info:eu-repo/semantics/article info:eu-repo/semantics/acceptedVersion (orcid)0000-0003-3211-0485 Julian, I. (orcid)0000-0002-8448-7543 Pellejero, I. Rho, H.S. Schlautmann, S. Tiggelaar, R.M. (orcid)0000-0001-9897-6527 Pina, M.P. Universidad de Zaragoza Gardeniers, H.J.G.E. (orcid)0000-0002-4758-9380 Mallada, R. Universidad de Zaragoza 5005 555 Universidad de Zaragoza Dpto. Ing.Quím.Tecnol.Med.Amb. Área Ingeniería Química 288, 1 (2019), 414-424 Sens. actuators, B, Chem. SENSORS AND ACTUATORS B-CHEMICAL 0925-4005 713643 http://zaguan.unizar.es/record/78022/files/texto_completo.pdf Postprint 71010 http://zaguan.unizar.es/record/78022/files/texto_completo.jpg?subformat=icon icon Postprint oai:zaguan.unizar.es:78022 articulos driver 2021-01-21-11:13:57 ARTICLE