000078169 001__ 78169
000078169 005__ 20200716101440.0
000078169 0247_ $$2doi$$a10.3390/nano9020161
000078169 0248_ $$2sideral$$a110915
000078169 037__ $$aART-2019-110915
000078169 041__ $$aeng
000078169 100__ $$aFedeli, E.
000078169 245__ $$aSelf-assembling hybrid linear-dendritic block copolymers: The design of nano-carriers for lipophilic antitumoral drugs
000078169 260__ $$c2019
000078169 5060_ $$aAccess copy available to the general public$$fUnrestricted
000078169 5203_ $$aTwo series of amphiphilic block copolymers with a hybrid linear-dendritic structure are presented. The compounds consisted of a hydrophilic poly (ethylene glycol) (PEG) block and a 2, 2 ' -bis(hydroxymethyl)propionic acid (bis-MPA) dendron functionalized with stearic acid chains that impart a hydrophobic nature to the block. Different self-assembled nanostructures with a hydrophobic interior and a hydrophilic external part were obtained depending on the length of the PEG chain (M n = 2000 and M n = 5000) and the generation of the bis-MPA dendron. The materials were characterized by transmission electron microscopy (TEM). The shapes of the aggregates ranged from spherical or cylindrical micelles to flexible bilayers. The hydrophobic core enabled these nanostructures to encapsulate the water-insoluble drug plitidepsin. The efficacy of these new plitidepsin-containing carriers was evaluated in four cancer cell-lines and they showed similar anticancer activity to the current standard drug formulation.
000078169 536__ $$9info:eu-repo/grantAgreement/ES/MINECO-FEDER/MAT2015-66208-C3-1-P$$9info:eu-repo/grantAgreement/ES/MINECO-FEDER/CTQ2015-70174-P$$9info:eu-repo/grantAgreement/ES/MECD/FPU12-05210$$9info:eu-repo/grantAgreement/EC/FP7/215884/EU/Functional liquid Crystalline dendrimers: Synthesis of New Materials, Resource for New Applications/DENDREAMERS$$9info:eu-repo/grantAgreement/ES/DGA/E47-17R
000078169 540__ $$9info:eu-repo/semantics/openAccess$$aby$$uhttp://creativecommons.org/licenses/by/3.0/es/
000078169 590__ $$a4.324$$b2019
000078169 592__ $$a0.858$$b2019
000078169 591__ $$aNANOSCIENCE & NANOTECHNOLOGY$$b42 / 103 = 0.408$$c2019$$dQ2$$eT2
000078169 593__ $$aMaterials Science (miscellaneous)$$c2019$$dQ1
000078169 591__ $$aMATERIALS SCIENCE, MULTIDISCIPLINARY$$b89 / 314 = 0.283$$c2019$$dQ2$$eT1
000078169 593__ $$aChemical Engineering (miscellaneous)$$c2019$$dQ1
000078169 655_4 $$ainfo:eu-repo/semantics/article$$vinfo:eu-repo/semantics/publishedVersion
000078169 700__ $$0(orcid)0000-0001-6584-6603$$aLancelot, A.
000078169 700__ $$aDominguez, J.M.
000078169 700__ $$0(orcid)0000-0001-9866-6633$$aSerrano, J.L.$$uUniversidad de Zaragoza
000078169 700__ $$aCalvo, P.
000078169 700__ $$0(orcid)0000-0001-7091-077X$$aSierra, T.$$uUniversidad de Zaragoza
000078169 7102_ $$12013$$2765$$aUniversidad de Zaragoza$$bDpto. Química Orgánica$$cÁrea Química Orgánica
000078169 773__ $$g9, 2 (2019), 161 [14 pp]$$pNanomaterials (Basel)$$tNanomaterials$$x2079-4991
000078169 8564_ $$s691443$$uhttps://zaguan.unizar.es/record/78169/files/texto_completo.pdf$$yVersión publicada
000078169 8564_ $$s109161$$uhttps://zaguan.unizar.es/record/78169/files/texto_completo.jpg?subformat=icon$$xicon$$yVersión publicada
000078169 909CO $$ooai:zaguan.unizar.es:78169$$particulos$$pdriver
000078169 951__ $$a2020-07-16-08:58:40
000078169 980__ $$aARTICLE