78169 20200716101440.0 doi 10.3390/nano9020161 sideral 110915 ART-2019-110915 eng Fedeli, E. Self-assembling hybrid linear-dendritic block copolymers: The design of nano-carriers for lipophilic antitumoral drugs 2019 Access copy available to the general public Unrestricted Two series of amphiphilic block copolymers with a hybrid linear-dendritic structure are presented. The compounds consisted of a hydrophilic poly (ethylene glycol) (PEG) block and a 2, 2 ' -bis(hydroxymethyl)propionic acid (bis-MPA) dendron functionalized with stearic acid chains that impart a hydrophobic nature to the block. Different self-assembled nanostructures with a hydrophobic interior and a hydrophilic external part were obtained depending on the length of the PEG chain (M n = 2000 and M n = 5000) and the generation of the bis-MPA dendron. The materials were characterized by transmission electron microscopy (TEM). The shapes of the aggregates ranged from spherical or cylindrical micelles to flexible bilayers. The hydrophobic core enabled these nanostructures to encapsulate the water-insoluble drug plitidepsin. The efficacy of these new plitidepsin-containing carriers was evaluated in four cancer cell-lines and they showed similar anticancer activity to the current standard drug formulation. info:eu-repo/grantAgreement/ES/MINECO-FEDER/MAT2015-66208-C3-1-P info:eu-repo/grantAgreement/ES/MINECO-FEDER/CTQ2015-70174-P info:eu-repo/grantAgreement/ES/MECD/FPU12-05210 info:eu-repo/grantAgreement/EC/FP7/215884/EU/Functional liquid Crystalline dendrimers: Synthesis of New Materials, Resource for New Applications/DENDREAMERS info:eu-repo/grantAgreement/ES/DGA/E47-17R info:eu-repo/semantics/openAccess by http://creativecommons.org/licenses/by/3.0/es/ 4.324 2019 0.858 2019 NANOSCIENCE & NANOTECHNOLOGY 42 / 103 = 0.408 2019 Q2 T2 Materials Science (miscellaneous) 2019 Q1 MATERIALS SCIENCE, MULTIDISCIPLINARY 89 / 314 = 0.283 2019 Q2 T1 Chemical Engineering (miscellaneous) 2019 Q1 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion (orcid)0000-0001-6584-6603 Lancelot, A. Dominguez, J.M. (orcid)0000-0001-9866-6633 Serrano, J.L. Universidad de Zaragoza Calvo, P. (orcid)0000-0001-7091-077X Sierra, T. Universidad de Zaragoza 2013 765 Universidad de Zaragoza Dpto. Química Orgánica Área Química Orgánica 9, 2 (2019), 161 [14 pp] Nanomaterials (Basel) Nanomaterials 2079-4991 691443 http://zaguan.unizar.es/record/78169/files/texto_completo.pdf Versión publicada 109161 http://zaguan.unizar.es/record/78169/files/texto_completo.jpg?subformat=icon icon Versión publicada oai:zaguan.unizar.es:78169 articulos driver 2020-07-16-08:58:40 ARTICLE