000078241 001__ 78241
000078241 005__ 20200103141021.0
000078241 0247_ $$2doi$$a10.1016/j.snb.2017.09.104
000078241 0248_ $$2sideral$$a102122
000078241 037__ $$aART-2018-102122
000078241 041__ $$aeng
000078241 100__ $$aMoya, Ana
000078241 245__ $$aMiniaturized multiparametric flexible platform for the simultaneous monitoring of ionic: Application in real urine
000078241 260__ $$c2018
000078241 5060_ $$aAccess copy available to the general public$$fUnrestricted
000078241 5203_ $$aBiomonitoring is a research topic that has largely relied on cell culture systems. Recently, the development of “Organ-on-a-Chip” (OC) platforms and the need for a continuous monitoring of these systems has increased its interest. However, the biomonitorization in these systems is still at its infancy due to the difficulty to adapt the sensors to microfluidic OC systems. In this work we have fabricated a modular, versatile, scalable, multi-analyte sensing platform, which integrates dissolved oxygen (DO), Na+, K+ and pH sensors for monitoring their concentrations in small volume of biological fluids. The platform is fabricated by means of rapid prototyping techniques using polymeric substrates, and incorporates all the necessary elements to measure the four analytes. It was designed with four gold sensing electrodes, and integrates a gold counter electrode and an Ag/AgCl pseudo-reference electrode for the electrochemical measurements in small volumes (0.83 µL) of samples. The sensors featured good sensitivities of 3.60 ± 0.2 nA (mg L-1) for DO and 69 ± 1 mV decade-1 for pH. Na+ and K+ µISE exhibited sensitivities of 57 ± 1 mV decade-1 and 52 ± 2 mV decade-1, and low limits of detection 5 × 10-6 M and 0.5 × 10-5 M respectively. This platform allows the dynamic measurement of the biological fluids parameters simultaneously, in real time and with a rapid response. The versatility of the platform allows its adaptation in any microfluidic cells culture systems. The novel multi-sensor platform has been validated in controlled buffers and with artificial urine (AU). A proof-of-concept using real mice urine (RU) has been carried out, demonstrating the good behaviour of the multi-sensing platform.
000078241 536__ $$9info:eu-repo/grantAgreement/ES/MINECO-FEDER/DPI2015-65401-C3-3-R$$9info:eu-repo/grantAgreement/ES/MINECO-FEDER/DPI2011-28262-C04$$9info:eu-repo/grantAgreement/ES/MINECO/BFU2007-62119$$9info:eu-repo/grantAgreement/ES/ICTS Network/MICRONANOFABS-MEINCOM$$9This project has received funding from the European Union’s Horizon 2020 research and innovation program under grant agreement No H2020 653626-microMole$$9info:eu-repo/grantAgreement/EC/H2020/653626/EU/SEWAGE MONITORING SYSTEM FOR TRACKING SYNTHETIC DRUG LABORATORIES/microMole$$9This project has received funding from the European Union’s Horizon 2020 research and innovation program under grant agreement No H2020 643694-HEARTEN$$9info:eu-repo/grantAgreement/EC/H2020/643694/EU/A co-operative mHEALTH environment targeting adherence and management of patients suffering from Heart Failure/HEARTEN$$9info:eu-repo/grantAgreement/ES/CSIC-IMB-CNM/ICTS NANBIOSIS-SU8 Unit-CIBER-BBN
000078241 540__ $$9info:eu-repo/semantics/openAccess$$aAll rights reserved$$uhttp://www.europeana.eu/rights/rr-f/
000078241 590__ $$a6.393$$b2018
000078241 591__ $$aCHEMISTRY, ANALYTICAL$$b6 / 84 = 0.071$$c2018$$dQ1$$eT1
000078241 591__ $$aINSTRUMENTS & INSTRUMENTATION$$b2 / 61 = 0.033$$c2018$$dQ1$$eT1
000078241 591__ $$aELECTROCHEMISTRY$$b4 / 26 = 0.154$$c2018$$dQ1$$eT1
000078241 592__ $$a1.389$$b2018
000078241 593__ $$aCondensed Matter Physics$$c2018$$dQ1
000078241 593__ $$aElectrical and Electronic Engineering$$c2018$$dQ1
000078241 593__ $$aElectronic, Optical and Magnetic Materials$$c2018$$dQ1
000078241 593__ $$aSurfaces, Coatings and Films$$c2018$$dQ1
000078241 593__ $$aMaterials Chemistry$$c2018$$dQ1
000078241 593__ $$aMetals and Alloys$$c2018$$dQ1
000078241 593__ $$aInstrumentation$$c2018$$dQ1
000078241 655_4 $$ainfo:eu-repo/semantics/article$$vinfo:eu-repo/semantics/acceptedVersion
000078241 700__ $$aIlla, Xavi
000078241 700__ $$0(orcid)0000-0002-6043-4869$$aGiménez, Ignacio$$uUniversidad de Zaragoza
000078241 700__ $$aLazo-Fernández, Yoskaly
000078241 700__ $$aVilla, Rosa
000078241 700__ $$aErrachid, Abdelhamid
000078241 700__ $$aGabriel, Gemma
000078241 7102_ $$11005$$2410$$aUniversidad de Zaragoza$$bDpto. Farmacología y Fisiolog.$$cÁrea Fisiología
000078241 773__ $$g255, 3 (2018), 2861-2870$$pSens. actuators, B, Chem.$$tSENSORS AND ACTUATORS B-CHEMICAL$$x0925-4005
000078241 8564_ $$s445161$$uhttps://zaguan.unizar.es/record/78241/files/texto_completo.pdf$$yPostprint
000078241 8564_ $$s101341$$uhttps://zaguan.unizar.es/record/78241/files/texto_completo.jpg?subformat=icon$$xicon$$yPostprint
000078241 909CO $$ooai:zaguan.unizar.es:78241$$particulos$$pdriver
000078241 951__ $$a2020-01-03-14:01:30
000078241 980__ $$aARTICLE