78261 20231215090947.0 doi 10.1016/j.ijbiomac.2017.09.103 sideral 104155 ART-2018-104155 eng Espona-Noguera, A. Tunable injectable alginate-based hydrogel for cell therapy in Type 1 Diabetes Mellitus 2018 Access copy available to the general public Unrestricted Islet transplantation has the potential of reestablishing naturally-regulated insulin production in Type 1 diabetic patients. Nevertheless, this procedure is limited due to the low islet survival after transplantation and the lifelong immunosuppression to avoid rejection. Islet embedding within a biocompatible matrix provides mechanical protection and a physical barrier against the immune system thus, increasing islet survival. Alginate is the preferred biomaterial used for embedding insulin-producing cells because of its biocompatibility, low toxicity and ease of gelation. However, alginate gelation is poorly controlled, affecting its physicochemical properties as an injectable biomaterial. Including different concentrations of the phosphate salt Na2HPO4 in alginate hydrogels, we can modulate their gelation time, tuning their physicochemical properties like stiffness and porosity while maintaining an appropriate injectability. Moreover, these hydrogels showed good biocompatibility when embedding a rat insulinoma cell line, especially at low Na2HPO4 concentrations, indicating that these hydrogels have potential as injectable biomaterials for Type 1 Diabetes Mellitus treatment. info:eu-repo/grantAgreement/ES/DGA/T88 info:eu-repo/grantAgreement/EC/H2020/645991/EU/Diabetes Reversing Implants with enhanced Viability and long-term Efficacy/DRIVE This project has received funding from the European Union’s Horizon 2020 research and innovation program under grant agreement No H2020 645991-DRIVE info:eu-repo/grantAgreement/ES/ISCII-CIBER/DRUGDIFF info:eu-repo/grantAgreement/ES/MINECO/BIO2016-79092-R info:eu-repo/grantAgreement/ES/MINECO/DPI2015-65401-C3-1-R info:eu-repo/semantics/openAccess All rights reserved http://www.europeana.eu/rights/rr-f/ 4.784 2018 BIOCHEMISTRY & MOLECULAR BIOLOGY 52 / 294 = 0.177 2018 Q1 T1 POLYMER SCIENCE 7 / 85 = 0.082 2018 Q1 T1 CHEMISTRY, APPLIED 9 / 70 = 0.129 2018 Q1 T1 0.962 2018 Biochemistry 2018 Q1 Structural Biology 2018 Q1 Molecular Biology 2018 Q1 Medicine (miscellaneous) 2018 Q1 info:eu-repo/semantics/article info:eu-repo/semantics/acceptedVersion Ciriza, J. (orcid)0000-0002-8666-622X Cañibano-Hernández, A. Fernandez, L. (orcid)0000-0002-4220-2722 Ochoa, I. Universidad de Zaragoza (orcid)0000-0003-2410-5678 Saenz del Burgo, L. Pedraz, J.L. 1003 443 Universidad de Zaragoza Dpto. Anatom.Histolog.Humanas Area Histología 107, PartA (2018), 1261-1269 Int. j. biol. macromol. International journal of biological macromolecules 0141-8130 716692 http://zaguan.unizar.es/record/78261/files/texto_completo.pdf Postprint 51662 http://zaguan.unizar.es/record/78261/files/texto_completo.jpg?subformat=icon icon Postprint oai:zaguan.unizar.es:78261 articulos driver 2023-12-15-08:57:20 ARTICLE