000078277 001__ 78277
000078277 005__ 20200117221646.0
000078277 0247_ $$2doi$$a10.1088/1748-605X/aa87e6
000078277 0248_ $$2sideral$$a104242
000078277 037__ $$aART-2018-104242
000078277 041__ $$aeng
000078277 100__ $$aGarcia-Gareta, E.
000078277 245__ $$aBiomimetic surface functionalization of clinically relevant metals used as orthopaedic and dental implants
000078277 260__ $$c2018
000078277 5060_ $$aAccess copy available to the general public$$fUnrestricted
000078277 5203_ $$aTitanium and its alloys or tantalum (Ta) are materials used in orthopaedic and dental implants due to their excellent mechanical properties and biocompatibility. However, their bioactivity and osteoconductivity is low. With a view to improving the bioactivity of these materials we hypothesised that the surface of Ta and TiAl6V4 can be functionalised with biomimetic, amorphous nano-sized calcium phosphate (CaP) apatite-like deposits, instead of creating uniform coatings, which can lead to flaking, delamination and poor adherence. We used Ta and TiAl6V4 metal discs with smooth and rough surfaces. Amorphous CaP apatite-like particles were deposited on the different surfaces by a biomimetic rapid two-step soaking method using concentrated simulated body fluid (SBF) solutions without a pre-treatment of the metal surfaces to induce CaP deposition. Immersion times in the second SBF solution of 48 and 18 h for Ta and TiAl6V4 respectively produced CaP deposits composed of amorphous globular nano-sized particles that also contained Mg, C and O. Longer immersion times produced more uniform coatings as well as an undesired calcite mineral phase. Prediction of in vivo behaviour by immersion in regular SBF showed that the obtained CaP deposits would act as a catalyst to rapidly form a Ca deficient CaP layer that also incorporates Mg. The amorphous CaP apatite-like deposits promoted initial attachment, proliferation and osteogenic differentiation of bone marrow derived mesenchymal stem cells. Finally, we used our method to functionalise 3D porous structures of titanium alloy made by selective laser sintering. Our study uses a novel and cost-effective approach to functionalise clinically relevant metal surfaces in order to increase the bioactivity of these materials, which could improve their clinical performance.
000078277 540__ $$9info:eu-repo/semantics/openAccess$$aAll rights reserved$$uhttp://www.europeana.eu/rights/rr-f/
000078277 590__ $$a3.44$$b2018
000078277 591__ $$aMATERIALS SCIENCE, BIOMATERIALS$$b14 / 32 = 0.438$$c2018$$dQ2$$eT2
000078277 591__ $$aENGINEERING, BIOMEDICAL$$b21 / 80 = 0.262$$c2018$$dQ2$$eT1
000078277 592__ $$a0.819$$b2018
000078277 593__ $$aBioengineering$$c2018$$dQ1
000078277 593__ $$aBiomaterials$$c2018$$dQ1
000078277 593__ $$aMechanics of Materials$$c2018$$dQ1
000078277 593__ $$aBusiness and International Management$$c2018$$dQ1
000078277 593__ $$aChemistry (miscellaneous)$$c2018$$dQ1
000078277 593__ $$aBiomedical Engineering$$c2018$$dQ1
000078277 655_4 $$ainfo:eu-repo/semantics/article$$vinfo:eu-repo/semantics/acceptedVersion
000078277 700__ $$aHua, J.
000078277 700__ $$0(orcid)0000-0001-8751-0983$$aOrera, A.$$uUniversidad de Zaragoza
000078277 700__ $$aKohli, N.
000078277 700__ $$aKnowles, J.C.
000078277 700__ $$aBlunn, G.W.
000078277 7102_ $$12003$$2395$$aUniversidad de Zaragoza$$bDpto. Física Materia Condensa.$$cÁrea Física Materia Condensada
000078277 773__ $$g13, 1 (2018), 015008 [14 pp]$$pBiomedical Materials$$tBiomedical Materials$$x1748-6041
000078277 8564_ $$s966621$$uhttps://zaguan.unizar.es/record/78277/files/texto_completo.pdf$$yPostprint
000078277 8564_ $$s55357$$uhttps://zaguan.unizar.es/record/78277/files/texto_completo.jpg?subformat=icon$$xicon$$yPostprint
000078277 909CO $$ooai:zaguan.unizar.es:78277$$particulos$$pdriver
000078277 951__ $$a2020-01-17-22:06:38
000078277 980__ $$aARTICLE