000078315 001__ 78315
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000078315 0247_ $$2doi$$a10.1016/j.jmbbm.2018.03.011
000078315 0248_ $$2sideral$$a105285
000078315 037__ $$aART-2018-105285
000078315 041__ $$aeng
000078315 100__ $$0(orcid)0000-0003-0978-3489$$aSimón-Allué, R.
000078315 245__ $$aMechanical behavior of surgical meshes for abdominal wall repair: In vivo versus biaxial characterization
000078315 260__ $$c2018
000078315 5060_ $$aAccess copy available to the general public$$fUnrestricted
000078315 5203_ $$aDespite the widespread use of synthetic meshes in the surgical treatment of the hernia pathology, the election criteria of a suitable mesh for specific patient continues to be uncertain. Thus, in this work, we propose a methodology to determine in advance potential disadvantages on the use of certain meshes based on the patient-specific abdominal geometry and the mechanical features of the certain meshes. To that purpose, we have first characterized the mechanical behavior of four synthetic meshes through biaxial tests. Secondly, two of these meshes were implanted in several New Zealand rabbits with a total defect previously created on the center of the abdominal wall. After the surgical procedure, specimen were subjected to in vivo pneumoperitoneum tests to determine the immediate post-surgical response of those meshes after implanted in a healthy specimen. Experimental performance was recorded by a stereo rig with the aim of obtaining quantitative information about the pressure-displacement relation of the abdominal wall. Finally, following the procedure presented in prior works (Simón-Allué et al., 2015, 2017), a finite element model was reconstructed from the experimental measurements and tests were computationally reproduced for the healthy and herniated cases. Simulations were compared and validated with the in vivo behavior and results were given along the abdominal wall in terms of displacements, stresses and strain. Mechanical characterization of the meshes revealed Surgipro TM as the most rigid implant and Neomesh SuperSoft® as the softer, while other two meshes (Neomesh Soft® Neopore®) remained in between. These two meshes were employed in the experimental study and resulted in similar effect in the abdominal wall cavity and both were close to the healthy case. Simulations confirmed this result while showed potential objections in the case of the other two meshes, due to high values in stresses or elongation that may led to discomfort in real tissue. The use of this methodology on human surgery may provide the surgeons with reliable and useful information to avoid certain meshes on specific-patient treatment.
000078315 536__ $$9info:eu-repo/grantAgreement/ES/CSIC-IMB-CNM/ICTS NANBIOSIS-SU8 Unit-CIBER-BBN$$9info:eu-repo/grantAgreement/ES/MEC/FPU13-03782$$9info:eu-repo/grantAgreement/ES/MINECO/BES-2012-053422$$9info:eu-repo/grantAgreement/ES/MINECO/DPI2014-54981-R$$9info:eu-repo/grantAgreement/ES/MINECO/DPI2017-84047-R
000078315 540__ $$9info:eu-repo/semantics/openAccess$$aby-nc-nd$$uhttp://creativecommons.org/licenses/by-nc-nd/3.0/es/
000078315 590__ $$a3.485$$b2018
000078315 591__ $$aENGINEERING, BIOMEDICAL$$b18 / 80 = 0.225$$c2018$$dQ1$$eT1
000078315 591__ $$aMATERIALS SCIENCE, BIOMATERIALS$$b13 / 32 = 0.406$$c2018$$dQ2$$eT2
000078315 592__ $$a1.037$$b2018
000078315 593__ $$aBiomaterials$$c2018$$dQ1
000078315 593__ $$aMechanics of Materials$$c2018$$dQ1
000078315 593__ $$aBiomedical Engineering$$c2018$$dQ1
000078315 655_4 $$ainfo:eu-repo/semantics/article$$vinfo:eu-repo/semantics/acceptedVersion
000078315 700__ $$aOrtillés, A.
000078315 700__ $$0(orcid)0000-0001-9713-1813$$aCalvo, B.$$uUniversidad de Zaragoza
000078315 7102_ $$15004$$2605$$aUniversidad de Zaragoza$$bDpto. Ingeniería Mecánica$$cÁrea Mec.Med.Cont. y Teor.Est.
000078315 773__ $$g82 (2018), 102-111$$pJ. mech. behav. boomed. mater.$$tJournal of the Mechanical Behavior of Biomedical Materials$$x1751-6161
000078315 8564_ $$s832666$$uhttps://zaguan.unizar.es/record/78315/files/texto_completo.pdf$$yPostprint
000078315 8564_ $$s89965$$uhttps://zaguan.unizar.es/record/78315/files/texto_completo.jpg?subformat=icon$$xicon$$yPostprint
000078315 909CO $$ooai:zaguan.unizar.es:78315$$particulos$$pdriver
000078315 951__ $$a2020-01-13-14:54:35
000078315 980__ $$aARTICLE