78341 20200217133051.0 doi 10.1016/j.drudis.2018.01.031 sideral 105480 ART-2018-105480 eng (orcid)0000-0002-0269-7337 Ruiz-Pesini, E. Universidad de Zaragoza Increasing mtDNA levels as therapy for mitochondrial optic neuropathies 2018 Access copy available to the general public Unrestricted Leber hereditary optic neuropathy (LHON) is a rare, inherited mitochondrial disease. No treatment has shown a clear-cut benefit on a clinically meaningful end-point. Primary open-angle glaucoma (POAG) is a frequent, acquired optic neuropathy. Lowering intraocular pressure (IOP) reduces disease progression. However, current methods to decelerate this progression are recognized as being inadequate. Therefore, there is a clear need to look for new therapeutic approaches. The growing evidence indicates that POAG can also be a mitochondrial optic neuropathy (MON). Several risk elements are common for both diseases and all of them decrease mitochondrial (mt)DNA content. Based on these susceptibility factors and their molecular mechanism, we suggest herein pharmacological therapies targeted to increase mtDNA levels, oxidative phosphorylation (OXPHOS) capability, and mitochondrial energy production as treatments for MONs. info:eu-repo/grantAgreement/ES/DGA/B33 info:eu-repo/grantAgreement/ES/DGA/FEDER info:eu-repo/grantAgreement/ES/ISCIII/PI14-00070 info:eu-repo/grantAgreement/ES/ISCIII/PI17-00021 info:eu-repo/grantAgreement/ES/ISCIII/PI17-00166 info:eu-repo/grantAgreement/ES/ISCIII/P114-00005 info:eu-repo/semantics/openAccess by-nc-nd http://creativecommons.org/licenses/by-nc-nd/3.0/es/ 6.88 2018 PHARMACOLOGY & PHARMACY 12 / 266 = 0.045 2018 Q1 T1 2.248 2018 Pharmacology 2018 Q1 Drug Discovery 2018 Q1 info:eu-repo/semantics/article info:eu-repo/semantics/acceptedVersion (orcid)0000-0001-5964-6138 Emperador, S. Universidad de Zaragoza (orcid)0000-0002-3217-1424 López-Gallardo, E. Universidad de Zaragoza (orcid)0000-0003-3524-5158 Hernández-Ainsa, C. Universidad de Zaragoza (orcid)0000-0003-1770-6299 Montoya, J. Universidad de Zaragoza 1003 443 Universidad de Zaragoza Dpto. Anatom.Histolog.Humanas Area Histología 1002 060 Universidad de Zaragoza Dpto. Bioq.Biolog.Mol. Celular Área Bioquímica y Biolog.Mole. 23, 3 (2018), 493-498 Drug discov. today DRUG DISCOVERY TODAY 1359-6446 420347 http://zaguan.unizar.es/record/78341/files/texto_completo.pdf Postprint 43759 http://zaguan.unizar.es/record/78341/files/texto_completo.jpg?subformat=icon icon Postprint oai:zaguan.unizar.es:78341 articulos driver 2020-02-17-12:42:55 ARTICLE