000078345 001__ 78345
000078345 005__ 20220525082804.0
000078345 0247_ $$2doi$$a10.1016/j.numecd.2018.02.006
000078345 0248_ $$2sideral$$a105370
000078345 037__ $$aART-2018-105370
000078345 041__ $$aeng
000078345 100__ $$0(orcid)0000-0002-3850-8235$$aRupérez, A.I.$$uUniversidad de Zaragoza
000078345 245__ $$aCardiovascular risk biomarkers and metabolically unhealthy status in prepubertal children: Comparison of definitions
000078345 260__ $$c2018
000078345 5060_ $$aAccess copy available to the general public$$fUnrestricted
000078345 5203_ $$aBackground and aims: The early onset of cardio-metabolic abnormalities, known as metabolically unhealthy (MU) status, is highly associated with obesity and cardiovascular disease (CVD), as well as with increased morbidity and mortality later in life. Given the lack of a consensus MU classification for prepubertal children, we aimed to compare available MU definitions in terms of their association with CVD risk biomarkers.
Methods and results: A total of 930 prepubertal children (622 with overweight/obesity, 462 males) aged 5–10.9 years were recruited, anthropometric measures were taken and biomarkers were analyzed. Children were classified using eight MU definitions based on different cut-offs for blood pressure, triacylglycerides, high-density lipoprotein cholesterol, glucose and homeostasis model assessment for insulin resistance (HOMA-IR). MU prevalence in children with overweight/obesity ranged between 30% and 60% across definitions. Plasma concentrations of resistin, leptin, myeloperoxidase (MPO) and total plasminogen activator inhibitor 1 (tPAI-1) were higher, and those of adiponectin were lower, in MU compared to MH children with overweight/obesity. Linear regression analyses confirmed the contribution of MPO and tPAI-1 concentrations to MU status, with most significant results derived from definitions that use age and sex-specific criteria and that account for HOMA-IR.
Conclusion: Plasma concentrations of MPO and tPAI-1 are increased in prepubertal MU children irrespective of having normal-weight or overweight/obesity. Inclusion of age and sex-specific cut-offs for cardio-metabolic components as well as insulin resistance criteria increases the quality of MU definitions as seen by their stronger association with CVD biomarkers concentrations.
000078345 536__ $$9info:eu-repo/grantAgreement/ES/CIBERObn/CB15-00043$$9info:eu-repo/grantAgreement/ES/CIBERObn/CB15-00131$$9info:eu-repo/grantAgreement/ES/ISCIII/PI11-02042$$9info:eu-repo/grantAgreement/ES/ISCIII/RD08-0072-0028$$9info:eu-repo/grantAgreement/ES/MINECO/FJCI-2014-19795
000078345 540__ $$9info:eu-repo/semantics/openAccess$$aby-nc-nd$$uhttp://creativecommons.org/licenses/by-nc-nd/3.0/es/
000078345 590__ $$a3.34$$b2018
000078345 591__ $$aCARDIAC & CARDIOVASCULAR SYSTEMS$$b50 / 136 = 0.368$$c2018$$dQ2$$eT2
000078345 591__ $$aNUTRITION & DIETETICS$$b33 / 86 = 0.384$$c2018$$dQ2$$eT2
000078345 591__ $$aENDOCRINOLOGY & METABOLISM$$b59 / 145 = 0.407$$c2018$$dQ2$$eT2
000078345 592__ $$a1.318$$b2018
000078345 593__ $$aCardiology and Cardiovascular Medicine$$c2018$$dQ1
000078345 593__ $$aNutrition and Dietetics$$c2018$$dQ1
000078345 593__ $$aMedicine (miscellaneous)$$c2018$$dQ1
000078345 593__ $$aEndocrinology, Diabetes and Metabolism$$c2018$$dQ1
000078345 655_4 $$ainfo:eu-repo/semantics/article$$vinfo:eu-repo/semantics/acceptedVersion
000078345 700__ $$aOlza, J.
000078345 700__ $$aGil-Campos, M.
000078345 700__ $$aLeis, R.
000078345 700__ $$0(orcid)0000-0002-0902-387X$$aBueno, G.$$uUniversidad de Zaragoza
000078345 700__ $$aAguilera, C.M.
000078345 700__ $$aGil, A.
000078345 700__ $$0(orcid)0000-0003-0454-653X$$aMoreno, L.A.$$uUniversidad de Zaragoza
000078345 7102_ $$11006$$2255$$aUniversidad de Zaragoza$$bDpto. Fisiatría y Enfermería$$cÁrea Enfermería
000078345 7102_ $$11010$$2670$$aUniversidad de Zaragoza$$bDpto. Pediatría Radiol.Med.Fís$$cÁrea Pediatría
000078345 773__ $$g28, 5 (2018), 524-530$$pNMCD, Nutr. Metab. Cardiovasc. Dis.$$tNUTRITION METABOLISM AND CARDIOVASCULAR DISEASES$$x0939-4753
000078345 8564_ $$s338175$$uhttps://zaguan.unizar.es/record/78345/files/texto_completo.pdf$$yPostprint
000078345 8564_ $$s8909$$uhttps://zaguan.unizar.es/record/78345/files/texto_completo.jpg?subformat=icon$$xicon$$yPostprint
000078345 909CO $$ooai:zaguan.unizar.es:78345$$particulos$$pdriver
000078345 951__ $$a2022-05-25-08:24:51
000078345 980__ $$aARTICLE