Template-based methodology for the simulation of intracorneal segment ring implantation in human corneas

Flecha-Lescún, J. (Universidad de Zaragoza) ; Calvo, B. (Universidad de Zaragoza) ; Zurita, J. ; Ariza-Gracia, M.Á.

Resumen: Keratoconus is an idiopathic, non-inflammatory and degenerative corneal disease characterised by a loss of the organisation in the corneal collagen fibrils. As a result, keratoconic corneas present a localised thinning and conical protrusion with irregular astigmatism and high myopia that worsen visual acuity. Intracorneal ring segments (ICRSs) are used in clinic to regularise the corneal surface and to prevent the disease from progressing. Unfortunately, the post-surgical effect of the ICRS is not explicitly accounted beforehand. Traditional treatments rely on population-based nomograms and the experience of the surgeon. In this vein, in silico models could be a clinical aid tool for clinicians to plan the intervention, or to test the post-surgical impact of different clinical scenarios. A semi-automatic computational methodology is presented in order to simulate the ICRS surgical operation and to predict the post-surgical optical outcomes. For the sake of simplicity, circular cross section rings, average corneas and an isotropic hyperelastic material are used. To determine whether the model behaves physiologically and to carry out a sensitivity analysis, a (Formula presented.) full-factorial analysis is carried out. In particular, how the stromal depth insertion, horizontal distance of ring insertion (hDRI) and diameter of the ring’s cross section ((Formula presented.)) are impacting in the spherical and cylindrical power of the cornea is analysed. Afterwards, the kinematics, mechanics and optics of keratoconic corneas after the ICRS insertion are analysed. Based on the parametric study, we can conclude that our model follows clinical trends previously reported. In particular and although there is an improvement in defocus, all corneas presented a change in their optical aberrations. The stromal depth insertion is the parameter that affects the corneal optics the most, whereas hDRI and (Formula presented.) are less important. Not only that, but it is almost impossible to achieve an optimal trade-off between spherical and cylindrical correction. Regarding the mechanical behaviour, inserting the rings at 65% depth or above will cause the cornea to slightly bend. This abnormal stress distribution greatly distorts the corneal optics and, more importantly, could be the cause of clinical problems such as corneal extrusion. Not only that, but our model also supports that rings are acting as restraint elements which relax the stresses of the corneal stroma in the cone of the disease. However, depending on the exact spatial location of the keratoconus, the insertion of rings could promote its evolution instead of preventing it. ICRS inserted deeper will prevent keratoconus in the posterior stroma from growing (relaxation of posterior surface), but will promote its growing if they are located in the anterior surface (increment of stress). In conclusion, the methodology proposed is suitable for simulating long-term mechanical and optical effects of ICRS insertion.

Idioma: Inglés

DOI: 10.1007/s10237-018-1013-z

Año: 2018

Publicado en: Biomechanics and Modeling in Mechanobiology 17, 4 (2018), 923-93
ISSN: 1617-7959

Factor impacto JCR: 2.829 (2018)

Categ. JCR: ENGINEERING, BIOMEDICAL rank: 28 / 80 = 0.35 (2018) - Q2 - T2
Categ. JCR: BIOPHYSICS rank: 26 / 72 = 0.361 (2018) - Q2 - T2

Factor impacto SCIMAGO: 1.001 - Biotechnology (Q1) - Modeling and Simulation (Q1) - Mechanical Engineering (Q1)

Financiación: info:eu-repo/grantAgreement/ES/DGA/T88
Financiación: info:eu-repo/grantAgreement/ES/MINECO/BES-2015-073630
Financiación: info:eu-repo/grantAgreement/ES/MINECO/DPI2014-54981-R
Financiación: info:eu-repo/grantAgreement/ES/MINECO/DPI2017-84047-R

Tipo y forma: Article (PostPrint)

Área (Departamento): Área Mec.Med.Cont. y Teor.Est. (Dpto. Ingeniería Mecánica)