000078723 001__ 78723
000078723 005__ 20240122154813.0
000078723 0247_ $$2doi$$a10.1016/j.trac.2017.12.004
000078723 0248_ $$2sideral$$a104154
000078723 037__ $$aART-2018-104154
000078723 041__ $$aeng
000078723 100__ $$0(orcid)0000-0002-7450-8769$$aResano, M.$$uUniversidad de Zaragoza
000078723 245__ $$aDried matrix spots and clinical elemental analysis. Current status, difficulties, and opportunities
000078723 260__ $$c2018
000078723 5060_ $$aAccess copy available to the general public$$fUnrestricted
000078723 5203_ $$aThis article examines the increasing importance of dried matrix spots (DMS), such as dried blood spots, dried urine spots, etc., in biomedical research, the challenges associated with their analysis when quantitative elemental information is aimed at, as well as the benefits deriving from the further usage of these types of samples. The article briefly reviews the historical evolution of this sampling approach in elemental clinical analysis, stressing prospective areas of applications (e.g., newborns or prosthesis control), the methodologies most recently developed to produce DMS of known volume, as well as novel strategies proposed to analyze them, often related to direct solid sampling techniques or fast lixiviation methods. Finally, the article discusses the type of information that could be obtained after isotopic analysis of DMS when targeting non-traditional stable isotopes (e.g., Cu, Fe or Zn), which can significantly help in the early diagnosis of some medical conditions (e.g. Wilson's disease).
000078723 536__ $$9info:eu-repo/grantAgreement/ES/DGA/FEDER$$9info:eu-repo/grantAgreement/ES/MINECO-FEDER/CTQ2015-64684-P
000078723 540__ $$9info:eu-repo/semantics/openAccess$$aAll rights reserved$$uhttp://www.europeana.eu/rights/rr-f/
000078723 590__ $$a8.428$$b2018
000078723 591__ $$aCHEMISTRY, ANALYTICAL$$b3 / 84 = 0.036$$c2018$$dQ1$$eT1
000078723 592__ $$a2.134$$b2018
000078723 593__ $$aAnalytical Chemistry$$c2018$$dQ1
000078723 593__ $$aSpectroscopy$$c2018$$dQ1
000078723 593__ $$aEnvironmental Chemistry$$c2018$$dQ1
000078723 655_4 $$ainfo:eu-repo/semantics/review$$vinfo:eu-repo/semantics/acceptedVersion
000078723 700__ $$0(orcid)0000-0002-5024-9598$$aBelarra, M.A.$$uUniversidad de Zaragoza
000078723 700__ $$0(orcid)0000-0003-2640-8496$$aGarcía-Ruiz, E.$$uUniversidad de Zaragoza
000078723 700__ $$0(orcid)0000-0002-3916-9992$$aAramendía, M.$$uUniversidad de Zaragoza
000078723 700__ $$aRello, L.
000078723 7102_ $$12009$$2750$$aUniversidad de Zaragoza$$bDpto. Química Analítica$$cÁrea Química Analítica
000078723 773__ $$g99 (2018), 75-87$$pTrAC, Trends anal. chem.$$tTRAC-TRENDS IN ANALYTICAL CHEMISTRY$$x0165-9936
000078723 8564_ $$s734734$$uhttps://zaguan.unizar.es/record/78723/files/texto_completo.pdf$$yPostprint
000078723 8564_ $$s69530$$uhttps://zaguan.unizar.es/record/78723/files/texto_completo.jpg?subformat=icon$$xicon$$yPostprint
000078723 909CO $$ooai:zaguan.unizar.es:78723$$particulos$$pdriver
000078723 951__ $$a2024-01-22-15:32:06
000078723 980__ $$aARTICLE