000078768 001__ 78768
000078768 005__ 20200117221630.0
000078768 0247_ $$2doi$$a10.1016/j.jcis.2018.03.107
000078768 0248_ $$2sideral$$a105922
000078768 037__ $$aART-2018-105922
000078768 041__ $$aeng
000078768 100__ $$0(orcid)0000-0002-9324-0446$$aAlejo, T.
000078768 245__ $$aControlled release of bupivacaine using hybrid thermoresponsive nanoparticles activated via photothermal heating
000078768 260__ $$c2018
000078768 5060_ $$aAccess copy available to the general public$$fUnrestricted
000078768 5203_ $$aNear-infrared (NIR) responsive nanoparticles are of great interest in the biomedical field as antennas for photothermal therapy and also as triggers for on-demand drug delivery. The present work reports the preparation of hollow gold nanoparticles (HGNPs) with plasmonic absorption in the NIR region covalently bound to a thermoresponsive polymeric shell that can be used as an on-demand drug delivery system for the release of analgesic drugs. The photothermal heating induced by the nanoparticles is able to produce the collapse of the polymeric shell thus generating the release of the local anesthetic bupivacaine in a spatiotemporally controlled way. Those HGNPs contain a 10 wt.% of polymer and present excellent reversible heating under NIR light excitation. Bupivacaine released at physiological temperature (37 °C) showed a pseudo-zero order release that could be spatiotemporally modified on-demand after applying several pulses of light/temperature above and below the lower critical solution temperature (LCST) of the polymeric shell. Furthermore, the nanomaterials obtained did not displayed detrimental effects on four mammalian cell lines at doses up to 0.2 mg/mL. From the results obtained it can be concluded than this type of hybrid thermoresponsive nanoparticle can be used as an externally activated on-demand drug delivery system.
000078768 536__ $$9info:eu-repo/grantAgreement/ES/ISCIII/CIBER-BBN$$9info:eu-repo/grantAgreement/EC/FP7/614715/EU/A Photo-triggered On-demand Drug Delivery System for Chronic Pain/NANOHEDONISM
000078768 540__ $$9info:eu-repo/semantics/openAccess$$aby-nc-nd$$uhttp://creativecommons.org/licenses/by-nc-nd/3.0/es/
000078768 590__ $$a6.361$$b2018
000078768 591__ $$aCHEMISTRY, PHYSICAL$$b29 / 148 = 0.196$$c2018$$dQ1$$eT1
000078768 592__ $$a1.29$$b2018
000078768 593__ $$aBiomaterials$$c2018$$dQ1
000078768 593__ $$aSurfaces, Coatings and Films$$c2018$$dQ1
000078768 593__ $$aElectronic, Optical and Magnetic Materials$$c2018$$dQ1
000078768 593__ $$aColloid and Surface Chemistry$$c2018$$dQ1
000078768 655_4 $$ainfo:eu-repo/semantics/article$$vinfo:eu-repo/semantics/acceptedVersion
000078768 700__ $$0(orcid)0000-0002-6275-1104$$aAndreu, V.
000078768 700__ $$0(orcid)0000-0003-2293-363X$$aMendoza, G.
000078768 700__ $$0(orcid)0000-0002-6873-5244$$aSebastian, V.$$uUniversidad de Zaragoza
000078768 700__ $$0(orcid)0000-0003-3165-0156$$aArruebo, M.$$uUniversidad de Zaragoza
000078768 7102_ $$15005$$2555$$aUniversidad de Zaragoza$$bDpto. Ing.Quím.Tecnol.Med.Amb.$$cÁrea Ingeniería Química
000078768 773__ $$g523 (2018), 234-244$$pJ. colloid interface sci.$$tJOURNAL OF COLLOID AND INTERFACE SCIENCE$$x0021-9797
000078768 8564_ $$s1228409$$uhttps://zaguan.unizar.es/record/78768/files/texto_completo.pdf$$yPostprint
000078768 8564_ $$s53105$$uhttps://zaguan.unizar.es/record/78768/files/texto_completo.jpg?subformat=icon$$xicon$$yPostprint
000078768 909CO $$ooai:zaguan.unizar.es:78768$$particulos$$pdriver
000078768 951__ $$a2020-01-17-21:59:11
000078768 980__ $$aARTICLE