78768 20200117221630.0 doi 10.1016/j.jcis.2018.03.107 sideral 105922 ART-2018-105922 eng (orcid)0000-0002-9324-0446 Alejo, T. Controlled release of bupivacaine using hybrid thermoresponsive nanoparticles activated via photothermal heating 2018 Access copy available to the general public Unrestricted Near-infrared (NIR) responsive nanoparticles are of great interest in the biomedical field as antennas for photothermal therapy and also as triggers for on-demand drug delivery. The present work reports the preparation of hollow gold nanoparticles (HGNPs) with plasmonic absorption in the NIR region covalently bound to a thermoresponsive polymeric shell that can be used as an on-demand drug delivery system for the release of analgesic drugs. The photothermal heating induced by the nanoparticles is able to produce the collapse of the polymeric shell thus generating the release of the local anesthetic bupivacaine in a spatiotemporally controlled way. Those HGNPs contain a 10 wt.% of polymer and present excellent reversible heating under NIR light excitation. Bupivacaine released at physiological temperature (37 °C) showed a pseudo-zero order release that could be spatiotemporally modified on-demand after applying several pulses of light/temperature above and below the lower critical solution temperature (LCST) of the polymeric shell. Furthermore, the nanomaterials obtained did not displayed detrimental effects on four mammalian cell lines at doses up to 0.2 mg/mL. From the results obtained it can be concluded than this type of hybrid thermoresponsive nanoparticle can be used as an externally activated on-demand drug delivery system. info:eu-repo/grantAgreement/ES/ISCIII/CIBER-BBN info:eu-repo/grantAgreement/EC/FP7/614715/EU/A Photo-triggered On-demand Drug Delivery System for Chronic Pain/NANOHEDONISM info:eu-repo/semantics/openAccess by-nc-nd http://creativecommons.org/licenses/by-nc-nd/3.0/es/ 6.361 2018 CHEMISTRY, PHYSICAL 29 / 148 = 0.196 2018 Q1 T1 1.29 2018 Biomaterials 2018 Q1 Surfaces, Coatings and Films 2018 Q1 Electronic, Optical and Magnetic Materials 2018 Q1 Colloid and Surface Chemistry 2018 Q1 info:eu-repo/semantics/article info:eu-repo/semantics/acceptedVersion (orcid)0000-0002-6275-1104 Andreu, V. (orcid)0000-0003-2293-363X Mendoza, G. (orcid)0000-0002-6873-5244 Sebastian, V. Universidad de Zaragoza (orcid)0000-0003-3165-0156 Arruebo, M. Universidad de Zaragoza 5005 555 Universidad de Zaragoza Dpto. Ing.Quím.Tecnol.Med.Amb. Área Ingeniería Química 523 (2018), 234-244 J. colloid interface sci. JOURNAL OF COLLOID AND INTERFACE SCIENCE 0021-9797 1228409 http://zaguan.unizar.es/record/78768/files/texto_completo.pdf Postprint 53105 http://zaguan.unizar.es/record/78768/files/texto_completo.jpg?subformat=icon icon Postprint oai:zaguan.unizar.es:78768 articulos driver 2020-01-17-21:59:11 ARTICLE