000078771 001__ 78771
000078771 005__ 20230830110637.0
000078771 0247_ $$2doi$$a10.1016/j.sleep.2018.01.014
000078771 0248_ $$2sideral$$a105940
000078771 037__ $$aART-2018-105940
000078771 041__ $$aeng
000078771 100__ $$aNascimento Ferreira, M.V.
000078771 245__ $$aAssociations between REV-ERBa, sleep duration and body mass index in European adolescents
000078771 260__ $$c2018
000078771 5060_ $$aAccess copy available to the general public$$fUnrestricted
000078771 5203_ $$aBackground/Objective: Although the REV-ERBa is considered an important regulator of both clock function and metabolism, its relationship with sleep duration and obesity is less clear. The objective of this study was to examine the association between the REV-ERBa clock gene and two outcomes – sleep duration and body mass index (BMI) – in European adolescents.
Methods: A sample of 831 adolescents (392 boys) aged 11.5–18.8 years from 10 European centers was used. The independent variables were REV-ERBa rs2071427 and rs2071570 SNPs, and their respective haplotypes. The outcomes were sleep duration and BMI.
Results: In girls, no significant association were found between rs2071427 or rs2071570 and the studied outcomes (p = 0.43). In boys, however, significant associations were found between rs2071570 and sleep duration (ß: -0.32 h/day for T minor allele carriers; p = 0.0017), and rs2071427 and BMI (ß: +0.72 kg/m2 for A minor allele carriers; p = 0.016). In the haplotype analysis, the TA haplotype (carrying the two minor alleles) was associated with both lower sleep duration (¿ = -0.38 h/day; p = 0.05) and higher BMI (¿ = +1.41 kg/m2; p = 0.018) in boys, when compared with the common CC haplotype.
Conclusions: The REV-ERBa rs2071427 and rs2071570 were associated with both sleep duration and BMI in boys. These findings confirmed the relevance of the REV-ERBa gene in human obesity, primarily in males, and also suggested that it has a potential role in affecting sleep duration.
000078771 536__ $$9info:eu-repo/grantAgreement/ES/MICINN-FEDER/GENUD Research Group$$9info:eu-repo/grantAgreement/EUR/FP6/FOOD-CT-2005-007034
000078771 540__ $$9info:eu-repo/semantics/openAccess$$aAll rights reserved$$uhttp://www.europeana.eu/rights/rr-f/
000078771 590__ $$a3.36$$b2018
000078771 591__ $$aCLINICAL NEUROLOGY$$b64 / 199 = 0.322$$c2018$$dQ2$$eT1
000078771 592__ $$a1.26$$b2018
000078771 593__ $$aMedicine (miscellaneous)$$c2018$$dQ1
000078771 655_4 $$ainfo:eu-repo/semantics/article$$vinfo:eu-repo/semantics/acceptedVersion
000078771 700__ $$aGoumidi, L.
000078771 700__ $$aCarvalho, H.B.
000078771 700__ $$aDe Moraes, A.C.F.
000078771 700__ $$0(orcid)0000-0002-0303-7912$$aSantaliestra-Pasías, A.M.$$uUniversidad de Zaragoza
000078771 700__ $$aKafatos, A.
000078771 700__ $$aMolnar, D.
000078771 700__ $$aLambrinou, C.-P.
000078771 700__ $$aDe Henauw, S.
000078771 700__ $$aGutierrez, A.
000078771 700__ $$aCensi, L.
000078771 700__ $$aMarcos, A.
000078771 700__ $$aWidhalm, K.
000078771 700__ $$aGottrand, F.
000078771 700__ $$aGonzalez-Gross, M.
000078771 700__ $$aMeirhaeghe, A.
000078771 700__ $$0(orcid)0000-0003-0454-653X$$aMoreno, L.A.$$uUniversidad de Zaragoza
000078771 7102_ $$11006$$2255$$aUniversidad de Zaragoza$$bDpto. Fisiatría y Enfermería$$cÁrea Enfermería
000078771 773__ $$g46 (2018), 56-60$$pSleep Med.$$tSLEEP MEDICINE$$x1389-9457
000078771 8564_ $$s171878$$uhttps://zaguan.unizar.es/record/78771/files/texto_completo.pdf$$yPostprint
000078771 8564_ $$s8194$$uhttps://zaguan.unizar.es/record/78771/files/texto_completo.jpg?subformat=icon$$xicon$$yPostprint
000078771 909CO $$ooai:zaguan.unizar.es:78771$$particulos$$pdriver
000078771 951__ $$a2023-08-30-10:57:37
000078771 980__ $$aARTICLE