000078781 001__ 78781
000078781 005__ 20191212100702.0
000078781 0247_ $$2doi$$a10.1021/acsami.7b18648
000078781 0248_ $$2sideral$$a104632
000078781 037__ $$aART-2018-104632
000078781 041__ $$aeng
000078781 100__ $$0(orcid)0000-0002-4170-7999$$aStepien, G.
000078781 245__ $$aEffect of surface chemistry and associated protein corona on the long-term biodegradation of iron oxide nanoparticles in Vivo
000078781 260__ $$c2018
000078781 5060_ $$aAccess copy available to the general public$$fUnrestricted
000078781 5203_ $$aThe protein corona formed on the surface of a nanoparticle in a biological medium determines its behavior in vivo. Herein, iron oxide nanoparticles containing the same core and shell, but bearing two different surface coatings, either glucose or poly(ethylene glycol), were evaluated. The nanoparticles' protein adsorption, in vitro degradation, and in vivo biodistribution and biotransformation over four months were investigated. Although both types of nanoparticles bound similar amounts of proteins in vitro, the differences in the protein corona composition correlated to the nanoparticles biodistribution in vivo. Interestingly, in vitro degradation studies demonstrated faster degradation for nanoparticles functionalized with glucose, whereas the in vivo results were opposite with accelerated biodegradation and clearance of the nanoparticles functionalized with poly(ethylene glycol). Therefore, the variation in the degradation rate observed in vivo could be related not only to the molecules attached to the surface, but also with the associated protein corona, as the key role of the adsorbed proteins on the magnetic core degradation has been demonstrated in vitro.
000078781 536__ $$9info:eu-repo/grantAgreement/ES/UZ/JIUZ-2014-CIE-03$$9info:eu-repo/grantAgreement/ES/MINECO/SAF2014-54763-C2-2-R$$9info:eu-repo/grantAgreement/ES/MINECO/SAF2014-54763-C2-1-R$$9info:eu-repo/grantAgreement/ES/MINECO/RYC-2014-15512$$9This project has received funding from the European Union’s Horizon 2020 research and innovation program under grant agreement No H2020 660228-HyHeat$$9info:eu-repo/grantAgreement/EC/H2020/660228/EU/Profiling gene expression in Hydra vulgaris following Gold Nanoparticle-mediated hyperthermia/HyHeat$$9This project has received funding from the European Union’s Horizon 2020 research and innovation program under grant agreement No H2020 657215-OUTstandINg$$9info:eu-repo/grantAgreement/EC/H2020/657215/EU/Cell-surface immobilized vs. internalized magnetic nanoparticles for magnetic hyperthermia studies/OUTstandINg$$9info:eu-repo/grantAgreement/EC/FP7/239931/EU/Multifunctional Magnetic Nanoparticles: Towards Smart Drugs Design/NANOPUZZLE$$9info:eu-repo/grantAgreement/ES/DGA/Fondo Social DGA-grupos DGA
000078781 540__ $$9info:eu-repo/semantics/openAccess$$aAll rights reserved$$uhttp://www.europeana.eu/rights/rr-f/
000078781 590__ $$a8.456$$b2018
000078781 591__ $$aNANOSCIENCE & NANOTECHNOLOGY$$b16 / 94 = 0.17$$c2018$$dQ1$$eT1
000078781 591__ $$aMATERIALS SCIENCE, MULTIDISCIPLINARY$$b27 / 293 = 0.092$$c2018$$dQ1$$eT1
000078781 592__ $$a2.596$$b2018
000078781 593__ $$aMaterials Science (miscellaneous)$$c2018$$dQ1
000078781 593__ $$aNanoscience and Nanotechnology$$c2018$$dQ1
000078781 593__ $$aMedicine (miscellaneous)$$c2018$$dQ1
000078781 655_4 $$ainfo:eu-repo/semantics/article$$vinfo:eu-repo/semantics/acceptedVersion
000078781 700__ $$0(orcid)0000-0002-2861-2469$$aMoros, M.$$uUniversidad de Zaragoza
000078781 700__ $$aPérez-Hernández, M.
000078781 700__ $$aMonge, M.
000078781 700__ $$0(orcid)0000-0003-2366-3598$$aGutiérrez, L.$$uUniversidad de Zaragoza
000078781 700__ $$0(orcid)0000-0001-5559-8757$$aFratila, R.M.
000078781 700__ $$0(orcid)0000-0003-3792-287X$$aLas Heras, M.D.$$uUniversidad de Zaragoza
000078781 700__ $$0(orcid)0000-0002-1817-4549$$aMenao Guillén, S.$$uUniversidad de Zaragoza
000078781 700__ $$0(orcid)0000-0002-7213-7095$$aPuente Lanzarote, J.J.
000078781 700__ $$aSolans, C.
000078781 700__ $$0(orcid)0000-0003-0154-0730$$aPardo, J.$$uUniversidad de Zaragoza
000078781 700__ $$0(orcid)0000-0003-1081-8482$$aMartínez De La Fuente, J.$$uUniversidad de Zaragoza
000078781 7102_ $$12009$$2750$$aUniversidad de Zaragoza$$bDpto. Química Analítica$$cÁrea Química Analítica
000078781 7102_ $$11009$$2773$$aUniversidad de Zaragoza$$bDpto. Patología Animal$$cÁrea Sanidad Animal
000078781 7102_ $$11008$$2566$$aUniversidad de Zaragoza$$bDpto. Microb.Med.Pr.,Sal.Públ.$$cÁrea Inmunología
000078781 7102_ $$12013$$2765$$aUniversidad de Zaragoza$$bDpto. Química Orgánica$$cÁrea Química Orgánica
000078781 7102_ $$11000$$2807$$aUniversidad de Zaragoza$$bDpto. Anat.Pat.Med.Leg.For.To.$$cArea Toxicología
000078781 773__ $$g10, 5 (2018), 4548-4560$$pACS appl. mater. interfaces$$tACS Applied Materials & Interfaces$$x1944-8244
000078781 8564_ $$s862846$$uhttps://zaguan.unizar.es/record/78781/files/texto_completo.pdf$$yPostprint
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000078781 909CO $$ooai:zaguan.unizar.es:78781$$particulos$$pdriver
000078781 951__ $$a2019-12-12-10:04:50
000078781 980__ $$aARTICLE