78781 20191212100702.0 doi 10.1021/acsami.7b18648 sideral 104632 ART-2018-104632 eng (orcid)0000-0002-4170-7999 Stepien, G. Effect of surface chemistry and associated protein corona on the long-term biodegradation of iron oxide nanoparticles in Vivo 2018 Access copy available to the general public Unrestricted The protein corona formed on the surface of a nanoparticle in a biological medium determines its behavior in vivo. Herein, iron oxide nanoparticles containing the same core and shell, but bearing two different surface coatings, either glucose or poly(ethylene glycol), were evaluated. The nanoparticles' protein adsorption, in vitro degradation, and in vivo biodistribution and biotransformation over four months were investigated. Although both types of nanoparticles bound similar amounts of proteins in vitro, the differences in the protein corona composition correlated to the nanoparticles biodistribution in vivo. Interestingly, in vitro degradation studies demonstrated faster degradation for nanoparticles functionalized with glucose, whereas the in vivo results were opposite with accelerated biodegradation and clearance of the nanoparticles functionalized with poly(ethylene glycol). Therefore, the variation in the degradation rate observed in vivo could be related not only to the molecules attached to the surface, but also with the associated protein corona, as the key role of the adsorbed proteins on the magnetic core degradation has been demonstrated in vitro. info:eu-repo/grantAgreement/ES/UZ/JIUZ-2014-CIE-03 info:eu-repo/grantAgreement/ES/MINECO/SAF2014-54763-C2-2-R info:eu-repo/grantAgreement/ES/MINECO/SAF2014-54763-C2-1-R info:eu-repo/grantAgreement/ES/MINECO/RYC-2014-15512 This project has received funding from the European Union’s Horizon 2020 research and innovation program under grant agreement No H2020 660228-HyHeat info:eu-repo/grantAgreement/EC/H2020/660228/EU/Profiling gene expression in Hydra vulgaris following Gold Nanoparticle-mediated hyperthermia/HyHeat This project has received funding from the European Union’s Horizon 2020 research and innovation program under grant agreement No H2020 657215-OUTstandINg info:eu-repo/grantAgreement/EC/H2020/657215/EU/Cell-surface immobilized vs. internalized magnetic nanoparticles for magnetic hyperthermia studies/OUTstandINg info:eu-repo/grantAgreement/EC/FP7/239931/EU/Multifunctional Magnetic Nanoparticles: Towards Smart Drugs Design/NANOPUZZLE info:eu-repo/grantAgreement/ES/DGA/Fondo Social DGA-grupos DGA info:eu-repo/semantics/openAccess All rights reserved http://www.europeana.eu/rights/rr-f/ 8.456 2018 NANOSCIENCE & NANOTECHNOLOGY 16 / 94 = 0.17 2018 Q1 T1 MATERIALS SCIENCE, MULTIDISCIPLINARY 27 / 293 = 0.092 2018 Q1 T1 2.596 2018 Materials Science (miscellaneous) 2018 Q1 Nanoscience and Nanotechnology 2018 Q1 Medicine (miscellaneous) 2018 Q1 info:eu-repo/semantics/article info:eu-repo/semantics/acceptedVersion (orcid)0000-0002-2861-2469 Moros, M. Universidad de Zaragoza Pérez-Hernández, M. Monge, M. (orcid)0000-0003-2366-3598 Gutiérrez, L. Universidad de Zaragoza (orcid)0000-0001-5559-8757 Fratila, R.M. (orcid)0000-0003-3792-287X Las Heras, M.D. Universidad de Zaragoza (orcid)0000-0002-1817-4549 Menao Guillén, S. Universidad de Zaragoza (orcid)0000-0002-7213-7095 Puente Lanzarote, J.J. Solans, C. (orcid)0000-0003-0154-0730 Pardo, J. Universidad de Zaragoza (orcid)0000-0003-1081-8482 Martínez De La Fuente, J. Universidad de Zaragoza 2009 750 Universidad de Zaragoza Dpto. Química Analítica Área Química Analítica 1009 773 Universidad de Zaragoza Dpto. Patología Animal Área Sanidad Animal 1008 566 Universidad de Zaragoza Dpto. Microb.Med.Pr.,Sal.Públ. Área Inmunología 2013 765 Universidad de Zaragoza Dpto. Química Orgánica Área Química Orgánica 1000 807 Universidad de Zaragoza Dpto. Anat.Pat.Med.Leg.For.To. Area Toxicología 10, 5 (2018), 4548-4560 ACS appl. mater. interfaces ACS Applied Materials & Interfaces 1944-8244 862846 http://zaguan.unizar.es/record/78781/files/texto_completo.pdf Postprint 55882 http://zaguan.unizar.es/record/78781/files/texto_completo.jpg?subformat=icon icon Postprint oai:zaguan.unizar.es:78781 articulos driver 2019-12-12-10:04:50 ARTICLE