Organocatalyzed Enantioselective Aldol and Henry Reactions Starting from Benzylic Alcohols

Alegre-Requena, J.V. ; Marqués-López, E. (Universidad de Zaragoza) ; Herrera, R.P. (Universidad de Zaragoza)

Resumen: Pioneering aldol and Henry reactions starting from benzylic-type alcohols are described. The aldol reaction has been successfully performed following a one-pot strategy starting from alcohols, while the Henry reaction has been carried out following a sequential protocol for the first time. In both processes, enantiomerically enriched products were obtained with good yields and high enantioselectivities. We have also demonstrated that in reactions sensitive to small amounts of acid the use of alcohols instead of aldehydes could be a good solution for improving the results of these reactions. (Figure presented.).

Idioma: Inglés

DOI: 10.1002/adsc.201701351

Año: 2018

Publicado en: Advanced Synthesis and Catalysis 360, 1 (2018), 124-129
ISSN: 1615-4150

Factor impacto JCR: 5.451 (2018)

Categ. JCR: CHEMISTRY, ORGANIC rank: 5 / 57 = 0.088 (2018) - Q1 - T1
Categ. JCR: CHEMISTRY, APPLIED rank: 4 / 71 = 0.056 (2018) - Q1 - T1

Factor impacto SCIMAGO: 1.817 - Organic Chemistry (Q1) - Catalysis (Q1)

Financiación: info:eu-repo/grantAgreement/ES/DGA/E104

Tipo y forma: Artículo (PostPrint)

Área (Departamento): Área Química Orgánica (Dpto. Química Orgánica)