78806 20200117221639.0 doi 10.1016/j.cma.2018.03.036 sideral 105921 ART-2018-105921 eng (orcid)0000-0003-3379-7688 González-Valverde, I. Universidad de Zaragoza Mechanical modeling of collective cell migration: An agent-based and continuum material approach 2018 Access copy available to the general public Unrestricted We develop a novel modeling approach that combines a discrete agent-based model and a continuum material model to simulate collective cell migration in epithelial layers. In this approach, cells are represented as particles located at their geometrical center, but also as a polygonal body derived from the Voronoi diagram. Furthermore, we model the tissue as a continuum medium with different spatial domains that represent cell and substrate materials. In fact, the mechanical behavior of each domain is affected by the presence of cells from the discrete model. Moreover, we solve this mechanical problem using the finite element method (FEM). The forces generated by cells are projected to the FE mesh, that is created dynamically during the simulation from the discrete cell representation. After the FE resolution, we use the mesh displacements to determine the new cell positions in the agent-based model. Finally, to demonstrate the potential of this approach to model epithelial tissue mechanics, we simulate two well-studied cases of collective cell migration: durotaxis and gap closure. We use the experimental data from the literature to validate our numerical results. Therefore, the modeling strategy here presented offers a new perspective for a deeper understanding of tissue mechanics that emerge from cell dynamics in epithelial layers. info:eu-repo/grantAgreement/ES/MINECO/DPI2015-64221-C2-1-R info:eu-repo/grantAgreement/EC/FP7/306571/EU/Predictive modelling and simulation in mechano-chemo-biology: a computer multi-approach/INSILICO-CELL info:eu-repo/semantics/openAccess by-nc-nd http://creativecommons.org/licenses/by-nc-nd/3.0/es/ 4.821 2018 MECHANICS 6 / 134 = 0.045 2018 Q1 T1 MATHEMATICS, INTERDISCIPLINARY APPLICATIONS 2 / 105 = 0.019 2018 Q1 T1 ENGINEERING, MULTIDISCIPLINARY 6 / 88 = 0.068 2018 Q1 T1 2.996 2018 Computational Mechanics 2018 Q1 Computer Science Applications 2018 Q1 Physics and Astronomy (miscellaneous) 2018 Q1 Mechanics of Materials 2018 Q1 Mechanical Engineering 2018 Q1 info:eu-repo/semantics/article info:eu-repo/semantics/acceptedVersion (orcid)0000-0002-9864-7683 García-Aznar, J.M. Universidad de Zaragoza 5004 605 Universidad de Zaragoza Dpto. Ingeniería Mecánica Área Mec.Med.Cont. y Teor.Est. 337 (2018), 246-262 Comput. methods appl. mech. eng. COMPUTER METHODS IN APPLIED MECHANICS AND ENGINEERING 0045-7825 1172011 http://zaguan.unizar.es/record/78806/files/texto_completo.pdf Postprint 38806 http://zaguan.unizar.es/record/78806/files/texto_completo.jpg?subformat=icon icon Postprint oai:zaguan.unizar.es:78806 articulos driver 2020-01-17-22:03:25 ARTICLE