000078825 001__ 78825
000078825 005__ 20220525082803.0
000078825 0247_ $$2doi$$a10.1038/s41598-019-40482-0
000078825 0248_ $$2sideral$$a111148
000078825 037__ $$aART-2019-111148
000078825 041__ $$aeng
000078825 100__ $$aRuiz-Ojeda, F.J.
000078825 245__ $$aEffects of X-chromosome Tenomodulin Genetic Variants on Obesity in a Children’s Cohort and Implications of the Gene in Adipocyte Metabolism
000078825 260__ $$c2019
000078825 5060_ $$aAccess copy available to the general public$$fUnrestricted
000078825 5203_ $$aTenomodulin (TNMD) is a type II transmembrane glycoprotein that has been recently linked to obesity, and it is highly expressed in obese adipose tissue. Several sex-dependent associations have been observed between single-nucleotide polymorphisms (SNPs) of the TNMD gene, which is located in the X-chromosome, and obesity, type 2 diabetes mellitus (T2DM), and metabolic syndrome in adults. On the other hand, results are lacking for children. We aimed (i) to study the association between TNMD genetic variants and metabolic complications related to childhood obesity and (ii) to investigate the function of TNMD in human adipocytes. We conducted a case-control, multicenter study in 915 Spanish children and demonstrated significant positive associations between TNMD genetic variants and BMI z-score, waist circumference, fasting glucose, and insulin resistance in boys, highlighting the SNP rs4828038. Additionally, we showed a BMI-adjusted inverse association with waist circumference in girls. Second, in vitro experiments revealed that TNMD is involved in adipogenesis, along with glucose and lipid metabolism in differentiated adipocytes, and these effects may be mediated through AMPK activation. Hence, these results suggest that TNMD genetic variants could be potentially useful as early life risk indicators for obesity and T2DM. In addition, we support the fact that TNMD exhibits significant metabolic functions in adipocytes.
000078825 536__ $$9info:eu-repo/grantAgreement/ES/ISCIII/RETICS-RD12-0026-0015$$9info:eu-repo/grantAgreement/ES/ISCIII/PI16-00871$$9info:eu-repo/grantAgreement/ES/ISCIII/PI11-02042$$9info:eu-repo/grantAgreement/ES/ISCIII/PI051968$$9info:eu-repo/grantAgreement/ES/ISCIII/PI020826
000078825 540__ $$9info:eu-repo/semantics/openAccess$$aby$$uhttp://creativecommons.org/licenses/by/3.0/es/
000078825 590__ $$a3.998$$b2019
000078825 592__ $$a1.341$$b2019
000078825 591__ $$aMULTIDISCIPLINARY SCIENCES$$b17 / 71 = 0.239$$c2019$$dQ1$$eT1
000078825 593__ $$aMultidisciplinary$$c2019$$dQ1
000078825 655_4 $$ainfo:eu-repo/semantics/article$$vinfo:eu-repo/semantics/publishedVersion
000078825 700__ $$aAnguita-Ruiz, A.
000078825 700__ $$0(orcid)0000-0002-3850-8235$$aRupérez, A.I.$$uUniversidad de Zaragoza
000078825 700__ $$aGomez-Llorente, C.
000078825 700__ $$aOlza, J.
000078825 700__ $$aVázquez-Cobela, R.
000078825 700__ $$aGil-Campos, M.
000078825 700__ $$0(orcid)0000-0002-0902-387X$$aBueno, G.$$uUniversidad de Zaragoza
000078825 700__ $$aLeis, R.
000078825 700__ $$aCañete, R.
000078825 700__ $$0(orcid)0000-0003-0454-653X$$aMoreno, L.A.$$uUniversidad de Zaragoza
000078825 700__ $$aGil, A.
000078825 700__ $$aAguilera, C.M.
000078825 7102_ $$11006$$2255$$aUniversidad de Zaragoza$$bDpto. Fisiatría y Enfermería$$cÁrea Enfermería
000078825 7102_ $$11010$$2670$$aUniversidad de Zaragoza$$bDpto. Pediatría Radiol.Med.Fís$$cÁrea Pediatría
000078825 773__ $$g9, 1 (2019), 3979 [16 pp]$$pSci. rep.$$tScientific Reports$$x2045-2322
000078825 8564_ $$s897030$$uhttps://zaguan.unizar.es/record/78825/files/texto_completo.pdf$$yVersión publicada
000078825 8564_ $$s109588$$uhttps://zaguan.unizar.es/record/78825/files/texto_completo.jpg?subformat=icon$$xicon$$yVersión publicada
000078825 909CO $$ooai:zaguan.unizar.es:78825$$particulos$$pdriver
000078825 951__ $$a2022-05-25-08:24:12
000078825 980__ $$aARTICLE