000078829 001__ 78829
000078829 005__ 20221004075831.0
000078829 0247_ $$2doi$$a10.1038/s41598-019-39346-4
000078829 0248_ $$2sideral$$a111154
000078829 037__ $$aART-2019-111154
000078829 041__ $$aeng
000078829 100__ $$aLope, V.
000078829 245__ $$aOvereating, caloric restriction and breast cancer risk by pathologic subtype: the EPIGEICAM study
000078829 260__ $$c2019
000078829 5060_ $$aAccess copy available to the general public$$fUnrestricted
000078829 5203_ $$aThis study analyzes the association of excessive energy intake and caloric restriction with breast cancer (BC) risk taking into account the individual energy needs of Spanish women. We conducted a multicenter matched case-control study where 973 pairs completed lifestyle and food frequency questionnaires. Expected caloric intake was predicted from a linear regression model in controls, including calories consumed as dependent variable, basal metabolic rate as an offset and physical activity as explanatory. Overeating and caloric restriction were defined taking into account the 99% confidence interval of the predicted value. The association with BC risk, overall and by pathologic subtype, was evaluated using conditional and multinomial logistic regression models. While premenopausal women that consumed few calories (>20% below predicted) had lower BC risk (OR = 0.36; 95% CI = 0.21–0.63), postmenopausal women with an excessive intake (=40% above predicted) showed an increased risk (OR = 2.81; 95% CI = 1.65–4.79). For every 20% increase in relative (observed/predicted) caloric intake the risk of hormone receptor positive (p-trend < 0.001) and HER2+ (p-trend = 0.015) tumours increased 13%, being this figure 7% for triple negative tumours. While high energy intake increases BC risk, caloric restriction could be protective. Moderate caloric restriction, in combination with regular physical activity, could be a good strategy for BC prevention.
000078829 536__ $$9info:eu-repo/grantAgreement/ES/MINECO/IJCI-2014-20900
000078829 540__ $$9info:eu-repo/semantics/openAccess$$aby$$uhttp://creativecommons.org/licenses/by/3.0/es/
000078829 590__ $$a3.998$$b2019
000078829 592__ $$a1.341$$b2019
000078829 591__ $$aMULTIDISCIPLINARY SCIENCES$$b17 / 71 = 0.239$$c2019$$dQ1$$eT1
000078829 593__ $$aMultidisciplinary$$c2019$$dQ1
000078829 655_4 $$ainfo:eu-repo/semantics/article$$vinfo:eu-repo/semantics/publishedVersion
000078829 700__ $$aMartín, M.
000078829 700__ $$aCastelló, A.
000078829 700__ $$aRuiz, A.
000078829 700__ $$aCasas, A.M.
000078829 700__ $$aBaena-Cañada, J.M.
000078829 700__ $$aAntolín, S.
000078829 700__ $$aRamos-Vázquez, M.
000078829 700__ $$aGarcía-Sáenz, J.Á.
000078829 700__ $$aMuñoz, M.
000078829 700__ $$aLluch, A.
000078829 700__ $$ade Juan-Ferré, A.
000078829 700__ $$aJara, C.
000078829 700__ $$aSánchez-Rovira, P.
000078829 700__ $$0(orcid)0000-0002-9159-4988$$aAntón, A.$$uUniversidad de Zaragoza
000078829 700__ $$aChacón, J.I.
000078829 700__ $$aArcusa, A.
000078829 700__ $$aJimeno, M.ªA.
000078829 700__ $$aBezares, S.
000078829 700__ $$aVioque, J.
000078829 700__ $$aCarrasco, E.
000078829 700__ $$aPérez-Gómez, B.
000078829 700__ $$aPollán, M.
000078829 7102_ $$11007$$2610$$aUniversidad de Zaragoza$$bDpto. Medicina, Psiqu. y Derm.$$cArea Medicina
000078829 773__ $$g9, 1 (2019), 3904 [9 pp]$$pSci. rep.$$tScientific Reports$$x2045-2322
000078829 8564_ $$s285674$$uhttps://zaguan.unizar.es/record/78829/files/texto_completo.pdf$$yVersión publicada
000078829 8564_ $$s117070$$uhttps://zaguan.unizar.es/record/78829/files/texto_completo.jpg?subformat=icon$$xicon$$yVersión publicada
000078829 909CO $$ooai:zaguan.unizar.es:78829$$particulos$$pdriver
000078829 951__ $$a2022-10-03-13:16:22
000078829 980__ $$aARTICLE