000078886 001__ 78886
000078886 005__ 20200217133048.0
000078886 0247_ $$2doi$$a10.1016/j.carbpol.2016.09.084
000078886 0248_ $$2sideral$$a96695
000078886 037__ $$aART-2017-96695
000078886 041__ $$aeng
000078886 100__ $$aZamora-Mora, Vanessa
000078886 245__ $$aChitosan nanoparticles for combined drug delivery and magnetic hyperthermia: from preparation to in vitro studies
000078886 260__ $$c2017
000078886 5060_ $$aAccess copy available to the general public$$fUnrestricted
000078886 5203_ $$aChitosan nanoparticles (CSNPs) ionically crosslinked with tripolyphosphate salts (TPP) were employed as nanocarriers in combined drug delivery and magnetic hyperthermia (MH) therapy. To that aim, three different ferrofluid concentrations and a constant 5-fluorouracil (5-FU) concentration were efficiently encapsulated to yield magnetic CSNPs with core-shell morphology. In vitro experiments using normal cells, fibroblasts (FHB) and cancer cells, human glioblastoma A-172, showed that CSNPs presented a dose-dependent cytotoxicity and that they were successfully uptaken into both cell lines. The application of a MH treatment in A-172 cells resulted in a cell viability of 67–75% whereas no significant reduction of cell viability was observed for FHB. However, the A-172 cells showed re-growth populations 4 h after the application of the MH treatment when CSNPs were loaded only with ferrofluid. Finally, a combined effect of MH and 5-FU release was observed with the application of a second MH treatment for CSNPs exhibiting a lower amount of released 5-FU. This result demonstrates the potential of CSNPs for the improvement of MH therapies.
000078886 536__ $$9info:eu-repo/grantAgreement/ES/MINECO/MAT2011-24797$$9info:eu-repo/grantAgreement/ES/MINECO/MAT2010-19326
000078886 540__ $$9info:eu-repo/semantics/openAccess$$aby-nc-nd$$uhttp://creativecommons.org/licenses/by-nc-nd/3.0/es/
000078886 590__ $$a5.158$$b2017
000078886 591__ $$aCHEMISTRY, APPLIED$$b2 / 71 = 0.028$$c2017$$dQ1$$eT1
000078886 591__ $$aPOLYMER SCIENCE$$b7 / 87 = 0.08$$c2017$$dQ1$$eT1
000078886 591__ $$aCHEMISTRY, ORGANIC$$b6 / 57 = 0.105$$c2017$$dQ1$$eT1
000078886 592__ $$a1.428$$b2017
000078886 593__ $$aMaterials Chemistry$$c2017$$dQ1
000078886 593__ $$aPolymers and Plastics$$c2017$$dQ1
000078886 593__ $$aOrganic Chemistry$$c2017$$dQ1
000078886 655_4 $$ainfo:eu-repo/semantics/article$$vinfo:eu-repo/semantics/acceptedVersion
000078886 700__ $$aFernández-Gutiérrez, Mar
000078886 700__ $$aGonzález-Gómez, Álvaro
000078886 700__ $$0(orcid)0000-0002-5578-7635$$aSanz, Beatriz
000078886 700__ $$aSan Román, Julio
000078886 700__ $$0(orcid)0000-0003-1558-9279$$aGoya, Gerardo F.$$uUniversidad de Zaragoza
000078886 700__ $$aHernández, Rebeca
000078886 700__ $$aMijangos, Carmen
000078886 7102_ $$12003$$2395$$aUniversidad de Zaragoza$$bDpto. Física Materia Condensa.$$cÁrea Física Materia Condensada
000078886 773__ $$g157 (2017), 361-370 [34 p.]$$pCarbohydr. polym.$$tCARBOHYDRATE POLYMERS$$x0144-8617
000078886 8564_ $$s1464857$$uhttps://zaguan.unizar.es/record/78886/files/texto_completo.pdf$$yPostprint
000078886 8564_ $$s57580$$uhttps://zaguan.unizar.es/record/78886/files/texto_completo.jpg?subformat=icon$$xicon$$yPostprint
000078886 909CO $$ooai:zaguan.unizar.es:78886$$particulos$$pdriver
000078886 951__ $$a2020-02-17-12:41:58
000078886 980__ $$aARTICLE