000078920 001__ 78920
000078920 005__ 20200117221641.0
000078920 0247_ $$2doi$$a10.1016/j.vetmic.2018.04.018
000078920 0248_ $$2sideral$$a105935
000078920 037__ $$aART-2018-105935
000078920 041__ $$aeng
000078920 100__ $$0(orcid)0000-0001-5028-947X$$aCalvete, C.
000078920 245__ $$aRabbit haemorrhagic disease: Cross-protection and comparative pathogenicity of GI.2/RHDV2/b and GI.1b/RHDV lagoviruses in a challenge trial
000078920 260__ $$c2018
000078920 5060_ $$aAccess copy available to the general public$$fUnrestricted
000078920 5203_ $$aEuropean rabbits (Oryctolagus cuniculus) are severely affected by rabbit haemorrhagic disease (RHD). Caused by a lagovirus, the disease leads to losses in the rabbit industry and has implications for wildlife conservation. Past RHD outbreaks have been caused by GI.1/RHDV genotype viruses. A new virus belonging to the GI.2/RHDV2/b genotype emerged in 2010, quickly spreading and replacing the former in several countries; however, limited data are available on its pathogenicity and epidemiological factors. The present work extends these issues and evaluates cross-protection between both genotypes. Ninety-four and 88 domestic rabbits were challenged with GI.2/RHDV2/b and GI.1b/RHDV variant isolates, respectively. Cross-protection was determined by a second challenge on survivors with the corresponding strain. Mortality by GI.2/RHDV2/b was highly variable due to unknown individual factors, whereas mortality by GI.1b/RHDV was associated with age. Mortality in rabbits < 4 weeks old was 84%, higher than previously reported. Cross-protection was not identical between the two viruses because the ratio of mortality rate ratios for the first and second challenges was 3.80 ± 2.68 times higher for GI.2/RHDV2/b than it was for GI.1b/RHDV. Rabbit susceptibility to GI.2/RHDV2/b varied greatly and appeared to be modulated by the innate functionality of the immune response and/or its prompt activation by other pathogens. GI.1b/RHDV pathogenicity appeared to be associated with undetermined age-related factors. These results suggest that GI.2/RHDV2/b may interact with other pathogens at the population level but does not satisfactorily explain the GI.1b/RHDV virus's quick replacement.
000078920 536__ $$9info:eu-repo/grantAgreement/ES/INIA/RZ2010-00009-00-00
000078920 540__ $$9info:eu-repo/semantics/openAccess$$aby-nc-nd$$uhttp://creativecommons.org/licenses/by-nc-nd/3.0/es/
000078920 590__ $$a2.791$$b2018
000078920 591__ $$aVETERINARY SCIENCES$$b7 / 141 = 0.05$$c2018$$dQ1$$eT1
000078920 591__ $$aMICROBIOLOGY$$b67 / 133 = 0.504$$c2018$$dQ3$$eT2
000078920 592__ $$a1.166$$b2018
000078920 593__ $$aMedicine (miscellaneous)$$c2018$$dQ1
000078920 593__ $$aVeterinary (miscellaneous)$$c2018$$dQ1
000078920 593__ $$aMicrobiology$$c2018$$dQ1
000078920 655_4 $$ainfo:eu-repo/semantics/article$$vinfo:eu-repo/semantics/acceptedVersion
000078920 700__ $$aMendoza, M.
000078920 700__ $$aAlcaraz, A.
000078920 700__ $$aSarto, M.P.
000078920 700__ $$0(orcid)0000-0002-5490-5177$$aJiménez-de-Bagüéss, M.P.
000078920 700__ $$aCalvo, A.J.
000078920 700__ $$aMonroy, F.
000078920 700__ $$0(orcid)0000-0001-9513-0219$$aCalvo, J.H.
000078920 773__ $$g219 (2018), 87-95$$pVet. microbiol.$$tVeterinary Microbiology$$x0378-1135
000078920 8564_ $$s416349$$uhttps://zaguan.unizar.es/record/78920/files/texto_completo.pdf$$yPostprint
000078920 8564_ $$s52657$$uhttps://zaguan.unizar.es/record/78920/files/texto_completo.jpg?subformat=icon$$xicon$$yPostprint
000078920 909CO $$ooai:zaguan.unizar.es:78920$$particulos$$pdriver
000078920 951__ $$a2020-01-17-22:04:11
000078920 980__ $$aARTICLE