000078956 001__ 78956
000078956 005__ 20230914083232.0
000078956 0247_ $$2doi$$a10.3390/cells8020154
000078956 0248_ $$2sideral$$a111337
000078956 037__ $$aART-2019-111337
000078956 041__ $$aeng
000078956 100__ $$0(orcid)0000-0002-5175-8394$$aAnel, A.$$uUniversidad de Zaragoza
000078956 245__ $$aRole of Exosomes in the Regulation of T-Cell Mediated Immune Responses and in Autoimmune Disease
000078956 260__ $$c2019
000078956 5060_ $$aAccess copy available to the general public$$fUnrestricted
000078956 5203_ $$aT-cell mediated immune responses should be regulated to avoid the development of autoimmune or chronic inflammatory diseases. Several mechanisms have been described to regulate this process, namely death of overactivated T cells by cytokine deprivation, suppression by T regulatory cells (Treg), induction of expression of immune checkpoint molecules such as CTLA-4 and PD-1, or activation-induced cell death (AICD). In addition, activated T cells release membrane microvesicles called exosomes during these regulatory processes. In this review, we revise the role of exosome secretion in the different pathways of immune regulation described to date and its importance in the prevention or development of autoimmune disease. The expression of membrane-bound death ligands on the surface of exosomes during AICD or the more recently described transfer of miRNA or even DNA inside T-cell exosomes is a molecular mechanism that will be analyzed.
000078956 536__ $$9info:eu-repo/grantAgreement/ES/DGA/B31-17R$$9info:eu-repo/grantAgreement/EUR/ERDF-ESF/Investing in your future$$9info:eu-repo/grantAgreement/ES/ISCIII/PI16-00526$$9info:eu-repo/grantAgreement/ES/MINECO/SAF2016-76338-R
000078956 540__ $$9info:eu-repo/semantics/openAccess$$aby$$uhttp://creativecommons.org/licenses/by/3.0/es/
000078956 590__ $$a4.366$$b2019
000078956 591__ $$aCELL BIOLOGY$$b70 / 194 = 0.361$$c2019$$dQ2$$eT2
000078956 655_4 $$ainfo:eu-repo/semantics/review$$vinfo:eu-repo/semantics/publishedVersion
000078956 700__ $$aGallego-Lleyda, A.
000078956 700__ $$ade Miguel, D.
000078956 700__ $$0(orcid)0000-0003-2156-8378$$aNaval, J.$$uUniversidad de Zaragoza
000078956 700__ $$aMartinez-Lostao, L.
000078956 7102_ $$11002$$2060$$aUniversidad de Zaragoza$$bDpto. Bioq.Biolog.Mol. Celular$$cÁrea Bioquímica y Biolog.Mole.
000078956 7102_ $$11002$$2050$$aUniversidad de Zaragoza$$bDpto. Bioq.Biolog.Mol. Celular$$cÁrea Biología Celular
000078956 773__ $$g8, 2 (2019), 154 [15 pp]$$pCells$$tCells$$x2073-4409
000078956 8564_ $$s419856$$uhttps://zaguan.unizar.es/record/78956/files/texto_completo.pdf$$yVersión publicada
000078956 8564_ $$s97931$$uhttps://zaguan.unizar.es/record/78956/files/texto_completo.jpg?subformat=icon$$xicon$$yVersión publicada
000078956 909CO $$ooai:zaguan.unizar.es:78956$$particulos$$pdriver
000078956 951__ $$a2023-09-13-10:44:38
000078956 980__ $$aARTICLE