78956 20230914083232.0 doi 10.3390/cells8020154 sideral 111337 ART-2019-111337 eng Anel, A. Universidad de Zaragoza (orcid)0000-0002-5175-8394 Role of Exosomes in the Regulation of T-Cell Mediated Immune Responses and in Autoimmune Disease 2019 Access copy available to the general public Unrestricted T-cell mediated immune responses should be regulated to avoid the development of autoimmune or chronic inflammatory diseases. Several mechanisms have been described to regulate this process, namely death of overactivated T cells by cytokine deprivation, suppression by T regulatory cells (Treg), induction of expression of immune checkpoint molecules such as CTLA-4 and PD-1, or activation-induced cell death (AICD). In addition, activated T cells release membrane microvesicles called exosomes during these regulatory processes. In this review, we revise the role of exosome secretion in the different pathways of immune regulation described to date and its importance in the prevention or development of autoimmune disease. The expression of membrane-bound death ligands on the surface of exosomes during AICD or the more recently described transfer of miRNA or even DNA inside T-cell exosomes is a molecular mechanism that will be analyzed. info:eu-repo/grantAgreement/ES/DGA/B31-17R info:eu-repo/grantAgreement/EUR/ERDF-ESF/Investing in your future info:eu-repo/grantAgreement/ES/ISCIII/PI16-00526 info:eu-repo/grantAgreement/ES/MINECO/SAF2016-76338-R info:eu-repo/semantics/openAccess by http://creativecommons.org/licenses/by/3.0/es/ 4.366 2019 CELL BIOLOGY 70 / 194 = 0.361 2019 Q2 T2 info:eu-repo/semantics/review info:eu-repo/semantics/publishedVersion Gallego-Lleyda, A. de Miguel, D. Naval, J. Universidad de Zaragoza (orcid)0000-0003-2156-8378 Martinez-Lostao, L. 1002 060 Universidad de Zaragoza Dpto. Bioq.Biolog.Mol. Celular Área Bioquímica y Biolog.Mole. 1002 050 Universidad de Zaragoza Dpto. Bioq.Biolog.Mol. Celular Área Biología Celular 8, 2 (2019), 154 [15 pp] Cells Cells 2073-4409 419856 http://zaguan.unizar.es/record/78956/files/texto_completo.pdf Versión publicada 97931 http://zaguan.unizar.es/record/78956/files/texto_completo.jpg?subformat=icon icon Versión publicada oai:zaguan.unizar.es:78956 articulos driver 2023-09-13-10:44:38 ARTICLE