000078961 001__ 78961
000078961 005__ 20200716101458.0
000078961 0247_ $$2doi$$a10.3389/fgene.2019.00118
000078961 0248_ $$2sideral$$a111352
000078961 037__ $$aART-2019-111352
000078961 041__ $$aeng
000078961 100__ $$aValls, Joan
000078961 245__ $$aAssociation of Candidate Gene Polymorphisms With Chronic Kidney Disease: Results of a Case-Control Analysis in the Nefrona Cohort
000078961 260__ $$c2019
000078961 5060_ $$aAccess copy available to the general public$$fUnrestricted
000078961 5203_ $$aChronic kidney disease (CKD) is a major risk factor for end-stage renal disease, cardiovascular disease and premature death. Despite classical clinical risk factors for CKD and some genetic risk factors have been identified, the residual risk observed in prediction models is still high. Therefore, new risk factors need to be identified in order to better predict the risk of CKD in the population. Here, we analyzed the genetic association of 79 SNPs of proteins associated with mineral metabolism disturbances with CKD in a cohort that includes 2, 445 CKD cases and 559 controls. Genotyping was performed with matrix assisted laser desorption ionizationtime of flight mass spectrometry. We used logistic regression models considering different genetic inheritance models to assess the association of the SNPs with the prevalence of CKD, adjusting for known risk factors. Eight SNPs (rs1126616, rs35068180, rs2238135, rs1800247, rs385564, rs4236, rs2248359, and rs1564858) were associated with CKD even after adjusting by sex, age and race. A model containing five of these SNPs (rs1126616, rs35068180, rs1800247, rs4236, and rs2248359), diabetes and hypertension showed better performance than models considering only clinical risk factors, significantly increasing the area under the curve of the model without polymorphisms. Furthermore, one of the SNPs (the rs2248359) showed an interaction with hypertension, being the risk genotype affecting only hypertensive patients. We conclude that 5 SNPs related to proteins implicated in mineral metabolism disturbances (Osteopontin, osteocalcin, matrix gla protein, matrix metalloprotease 3 and 24 hydroxylase) are associated to an increased risk of suffering CKD.
000078961 536__ $$9info:eu-repo/grantAgreement/ES/AbbVie-FEDER-ISCIII/FIS-PI10-00173$$9info:eu-repo/grantAgreement/ES/AbbVie-FEDER-ISCIII/FIS-PI16-01354$$9info:eu-repo/grantAgreement/ES/AbbVie-FEDER-ISCIII/RETIC-RD16-0009-NEFRONA
000078961 540__ $$9info:eu-repo/semantics/openAccess$$aby-nc-nd$$uhttp://creativecommons.org/licenses/by-nc-nd/3.0/es/
000078961 590__ $$a3.258$$b2019
000078961 591__ $$aGENETICS & HEREDITY$$b73 / 177 = 0.412$$c2019$$dQ2$$eT2
000078961 592__ $$a1.469$$b2019
000078961 593__ $$aMolecular Medicine$$c2019$$dQ1
000078961 593__ $$aGenetics$$c2019$$dQ2
000078961 593__ $$aGenetics (clinical)$$c2019$$dQ2
000078961 655_4 $$ainfo:eu-repo/semantics/article$$vinfo:eu-repo/semantics/publishedVersion
000078961 700__ $$aPerez-Guallar, Carles
000078961 700__ $$aCambray, Serafi
000078961 700__ $$aPerez-Guallar, Carles
000078961 700__ $$aBozic, Milica
000078961 700__ $$aBermudez-Lopez, Marcelino
000078961 700__ $$aFernandez, Elvira
000078961 700__ $$aBetriu, Angels
000078961 700__ $$aRodriguez, Isabel
000078961 700__ $$aValdivielso, Jose M.
000078961 700__ $$aAladren Regidor, Ma Jose
000078961 700__ $$aAlmirall, Jaume
000078961 700__ $$aPonz, Esther
000078961 700__ $$aArteaga Coloma, Jesus
000078961 700__ $$aBajo Rubio, Ma Auxiliadora
000078961 700__ $$aDiaz, Raquel Raquel
000078961 700__ $$aBelart Rodriguez, Montserrat
000078961 700__ $$aGascon, Antonio
000078961 700__ $$aBover Sanjuan, Jordi
000078961 700__ $$aBronsoms Artero, Josep
000078961 700__ $$aCabezuelo Romero, Juan B.
000078961 700__ $$aMuray Cases, Salome
000078961 700__ $$aCalvino Varela, Jesus
000078961 700__ $$aCaro Acevedo, Pilar
000078961 700__ $$aCarreras Bassa, Jordi
000078961 700__ $$aCases Amenos, Aleix
000078961 700__ $$aMasso Jimenez, Elisabet
000078961 700__ $$0(orcid)0000-0003-2557-8987$$aMoreno Lopez, Rosario$$uUniversidad de Zaragoza
000078961 700__ $$aCigarran Guldris, Secundino
000078961 700__ $$aLopez Prieto, Saray
000078961 700__ $$aComas Mongay, Lourdes
000078961 700__ $$aComerma, Isabel
000078961 700__ $$aCompte Jove, Ma Teresa
000078961 700__ $$aCuberes Izquierdo, Marta
000078961 700__ $$ade Alvaro, Fernando
000078961 700__ $$aHevia Ojanguren, Covadonga
000078961 700__ $$ade Arriba de la Fuente, Gabriel
000078961 700__ $$adel Pino y Pino, Ma Dolores
000078961 700__ $$aDiaz-Tejeiro Izquierdo, Rafael
000078961 700__ $$aAhijado Hormigos, Francisco
000078961 700__ $$aDotori, Marta
000078961 700__ $$aDuarte, Veronica
000078961 700__ $$aEstupinan Torres, Sara
000078961 700__ $$aFernandez Reyes, Ma Jose
000078961 700__ $$aFernandez Rodriguez, Ma Loreto
000078961 700__ $$aFernandez, Guillermina
000078961 700__ $$aGalan Serrano, Antonio
000078961 700__ $$aGarcia Canton, Cesar
000078961 700__ $$aGarcia Herrera, Antonio L.
000078961 700__ $$aGarcia Mena, Mercedes
000078961 700__ $$aGil Sacaluga, Luis
000078961 700__ $$aAguilar, Maria
000078961 700__ $$aGorriz, Jose Luis
000078961 700__ $$aHuarte Loza, Emma
000078961 700__ $$aLerma, Jose Luis
000078961 700__ $$aLiebana Canada, Antonio
000078961 700__ $$aMarin Alvarez, Jesus Pedro
000078961 700__ $$aMartin Alemany, Nadia
000078961 700__ $$aMartin Garcia, Jesus
000078961 700__ $$aMartinez Castelao, Alberto
000078961 700__ $$aMartinez Villaescusa, Maria
000078961 700__ $$aMartinez, Isabel
000078961 700__ $$aMoina Eguren, Inigo
000078961 700__ $$aMoreno Los Huertos, Silvia
000078961 700__ $$aMouzo Mirco, Ricardo
000078961 700__ $$aMunar Vila, Antonia
000078961 700__ $$aMunoz Diaz, Ana Beatriz
000078961 700__ $$aNavarro Gonzalez, Juan F.
000078961 700__ $$aNieto, Javier
000078961 700__ $$aCarreno, Agustin
000078961 700__ $$aNovoa Fernandez, Enrique
000078961 700__ $$aOrtiz, Alberto
000078961 700__ $$aFernandez, Beatriz
000078961 700__ $$aParaiso, Vicente
000078961 700__ $$aPerez Fontan, Miguel
000078961 700__ $$aPeris Domingo, Ana
000078961 700__ $$aPinera Haces, Celestino
000078961 700__ $$aPrados Garrido, Ma Dolores
000078961 700__ $$aPrieto Velasco, Mario
000078961 700__ $$aPuig Mari, Carmina
000078961 700__ $$aRivera Gorrin, Maite
000078961 700__ $$aRubio, Esther
000078961 700__ $$aRuiz, Pilar
000078961 700__ $$aSalgueira Lazo, Mercedes
000078961 700__ $$aMartinez Puerto, Ana Isabel
000078961 700__ $$aSanchez Tomero, Jose Antonio
000078961 700__ $$aSanchez, Jose Emilio
000078961 700__ $$aSans Lorman, Ramon
000078961 700__ $$aSaracho, Ramon
000078961 700__ $$aSarrias, Maria
000078961 700__ $$aSeron, Daniel
000078961 700__ $$aSoler, Maria Jose
000078961 700__ $$aBarrios, Clara
000078961 700__ $$aSousa, Fernando
000078961 700__ $$aToran, Daniel
000078961 700__ $$aTornero Molina, Fernando
000078961 700__ $$aUson Carrasco, Jose Javier
000078961 700__ $$aValera Cortes, Ildefonso
000078961 700__ $$aVilaprinyo del Perugia, Ma Merce
000078961 700__ $$aVirto Ruiz, Rafael C.
000078961 700__ $$aSantos Altozano, Carlos
000078961 700__ $$aArtigao Rodenas, Miguel
000078961 700__ $$aGil Gil, Ines
000078961 700__ $$aAdan Gil, Francisco
000078961 700__ $$aGarcia Criado, Emilio
000078961 700__ $$aDura Belinchon, Rafael
000078961 700__ $$aFernandez Toro, Jose Ma
000078961 700__ $$aDivison Garrote, Juan Antonio
000078961 7102_ $$11007$$2610$$aUniversidad de Zaragoza$$bDpto. Medicina, Psiqu. y Derm.$$cArea Medicina
000078961 773__ $$g10 (2019), 118 [10 pp]$$pFront. genet.$$tFrontiers in Genetics$$x1664-8021
000078961 8564_ $$s271997$$uhttps://zaguan.unizar.es/record/78961/files/texto_completo.pdf$$yVersión publicada
000078961 8564_ $$s25560$$uhttps://zaguan.unizar.es/record/78961/files/texto_completo.jpg?subformat=icon$$xicon$$yVersión publicada
000078961 909CO $$ooai:zaguan.unizar.es:78961$$particulos$$pdriver
000078961 951__ $$a2020-07-16-09:11:35
000078961 980__ $$aARTICLE