000078981 001__ 78981
000078981 005__ 20220908120452.0
000078981 0247_ $$2doi$$a10.1136/bmjopen-2018-023571
000078981 0248_ $$2sideral$$a111460
000078981 037__ $$aART-2019-111460
000078981 041__ $$aeng
000078981 100__ $$0(orcid)0000-0001-7293-701X$$aAguilar-Palacio, I.$$uUniversidad de Zaragoza
000078981 245__ $$aCo-prescription patterns of cardiovascular preventive treatments: A cross-sectional study in the Aragon worker' health study (Spain)
000078981 260__ $$c2019
000078981 5060_ $$aAccess copy available to the general public$$fUnrestricted
000078981 5203_ $$aObjectives: To identify cardiovascular disease (CVD) preventive treatments combinations, among them and with other drugs, and to determine their prevalence in a cohort of Spanish workers.
Design: Cross-sectional study. Setting Aragon Workers'' Health Study (AWHS) cohort in Spain. Participants 5577 workers belonging to AWHS cohort. From these subjects, we selected those that had, at least, three prescriptions of the same therapeutic subgroup in 2014 (n=4605). Primary and secondary outcome measures Drug consumption was obtained from the Aragon Pharmaceutical Consumption Registry (Farmasalud). In order to know treatment utilisation, prevalence analyses were conducted. Frequent item set mining techniques were applied to identify drugs co-prescription patterns. All the results were stratified by sex and age.
Results: 42.3% of men and 18.8% of women in the cohort received, at least, three prescriptions of a CVD preventive treatment in 2014. The most prescribed CVD treatment were antihypertensives (men: 28.2%, women 9.2%). The most frequent association observed among CVD preventive treatment was agents acting on the renin-angiotensin system and lipid-lowering drugs (5.1% of treated subjects). Co-prescription increased with age, especially after 50 years old, both in frequency and number of associations, and was higher in men. Regarding the association between CVD preventive treatments and other drugs, the most frequent pattern observed was lipid-lowering drugs and drugs used for acid related disorders (4.2% of treated subjects).
Conclusions: There is an important number of co-prescription patterns that involve CVD preventive treatments. These patterns increase with age and are more frequent in men. Mining techniques are a useful tool to identify pharmacological patterns that are not evident in the individual clinical practice, in order to improve drug prescription appropriateness.
000078981 536__ $$9info:eu-repo/grantAgreement/ES/ISCIII-FIS/PI13-01668$$9info:eu-repo/grantAgreement/ES/ISCIII-FIS/PI17-01704$$9info:eu-repo/grantAgreement/ES/DGA-GRISSA/B09-17R$$9info:eu-repo/grantAgreement/ES/DGA/B12-17R$$9info:eu-repo/grantAgreement/ES/DGA/B02-17R
000078981 540__ $$9info:eu-repo/semantics/openAccess$$aby-nc$$uhttp://creativecommons.org/licenses/by-nc/3.0/es/
000078981 590__ $$a2.496$$b2019
000078981 591__ $$aMEDICINE, GENERAL & INTERNAL$$b52 / 165 = 0.315$$c2019$$dQ2$$eT1
000078981 592__ $$a1.247$$b2019
000078981 593__ $$aMedicine (miscellaneous)$$c2019$$dQ1
000078981 655_4 $$ainfo:eu-repo/semantics/article$$vinfo:eu-repo/semantics/publishedVersion
000078981 700__ $$0(orcid)0000-0002-7194-8275$$aMalo, S.$$uUniversidad de Zaragoza
000078981 700__ $$0(orcid)0000-0001-7587-9716$$aLallana, M.
000078981 700__ $$0(orcid)0000-0002-2712-6709$$aFeja, C.
000078981 700__ $$aGonzález, J.
000078981 700__ $$0(orcid)0000-0003-0604-5042$$aMoreno-Franco, B.$$uUniversidad de Zaragoza
000078981 700__ $$0(orcid)0000-0002-6671-5661$$aRabanaque, M.$$uUniversidad de Zaragoza
000078981 7102_ $$11008$$2615$$aUniversidad de Zaragoza$$bDpto. Microb.Med.Pr.,Sal.Públ.$$cÁrea Medic.Prevent.Salud Públ.
000078981 773__ $$g9, 4 (2019), e023571 [8 pp]$$pBMJ Open$$tBMJ Open$$x2044-6055
000078981 8564_ $$s381877$$uhttps://zaguan.unizar.es/record/78981/files/texto_completo.pdf$$yVersión publicada
000078981 8564_ $$s128338$$uhttps://zaguan.unizar.es/record/78981/files/texto_completo.jpg?subformat=icon$$xicon$$yVersión publicada
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000078981 951__ $$a2022-09-08-11:53:49
000078981 980__ $$aARTICLE